Exhaustive risk evaluation of trans-fatty acid and glycidol fatty acid esther

2013 Fiscal Year Final Research Report

• Project/Area Number: 23500964
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits, studies on eating habits
• Research Institution: University of Shizuoka
• Principal Investigator: MASUDA Shuichi 静岡県立大学, 食品栄養科学部, 准教授 (40336657)
• Project Period (FY): 2011 – 2013
• Keywords: トランス脂肪酸 / グリシドール脂肪酸エステル / 遺伝毒性

Research Abstract

Trans-fatty acid (TFA) was detected in some dietary oils (0.3-1.93g/100g). However, the concentration of TFA was decreased by heating. Though glycidol fatty acid ester (GE) was determined in oils, the levelof GE was also decreased by heating. Treatment of GE showed the siginificantly genotoxcities (reverse mutation, DNA damages and the frequency of micronuclei) in Ames test(TA100), COMET assay and micronuclei test compared to non-treated groups. The concentration of GE in comminuted pig meat heated with charcoal firewas very high (195g/100g meat). From these results, it is demonstrated that we are habitually exposed to TFA and GE that have an influence on the health of human from daily foods. It is important to estimate the risk of these chemicals to human.

Research Products

• [Journal Article] In vivo examination of the genotoxicity of the urban air and surface soil pollutant, 3, 6-dinitrobenzo[e]pyrene, with intraperitoneal and intratracheal administration (2013)
  • Author(s): Kato T, Totsuka Y, Hasei T, Watanabe T, Wakabayashi K, Kinae N, Masuda S
  • Journal Title: Environ. Toxicol Volume: 28(10) Pages: 588-594
• [Journal Article] Genotoxicity of multi-walled carbon nanotubes in both in vitro and in vivo assay systems (2013)
  • Author(s): Kato T, Totsuka Y, Ishino K, Matsumoto Y, Tada Y, Nakae D, Goto S, Masuda S, Ogo S, Kawanishi M, Yagi T, Matsuda T, Watanabe M, Wakabayashi K
  • Journal Title: Nanotoxicology Volume: 7(4) Pages: 452-461
• [Journal Article] Change in Mutagenic Activity of Genistein after a Nitirite Treatment (2012)
  • Author(s): Masuda S, Shimamura Y , Kato T , Tan Yu-Feng , Iwamoto K , and Kinae N
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• [Journal Article] A new prenylflavonoid isolated from propolis collected in the Solomon Islands (2012)
  • Author(s): Inui S, Shimamura Y, Masuda S, Shirafuji K, Moli RT, Kumazawa S
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• [Journal Article] Solophenols B-D and solomonin: new prenylated polyphenols isolated from propolis collected from the Solomon Islands and their antibacterial activity (2012)
  • Author(s): Inui S, Hosoya T, Shimamura Y, Masuda S, Ogawa T, Kobayashi H, Shirafuji K, Moli RT, Kozone I, Shin-ya K, Kumazawa S
  • Journal Title: J. Agric. Food Chem Volume: 60(47) Pages: 11765-70
• [Journal Article] Genotoxicity of acrylamide in vitro: Acrylamide is not metabolically activated in standard in vitro systems (2011)
  • Author(s): Koyama N, Yasui M, Oda Y, Suzuki S, Satoh T, Suzuki T, Matsuda T, Masuda S, Kinae N, Honma M
  • Journal Title: Environ Mol Mutagen Volume: 52(1) Pages: 11-19
• [Journal Article] Acrylamide genotoxicity in young versus adult gpt delta male rats (2011)
  • Author(s): Koyama N, Yasui M, Kimura A, Takami S, Suzuki T, Masumura K, Nohmi T, Masuda S, Kinae N, Matsuda T, Imai T, Honma M
  • Journal Title: Mutagenesis Volume: 26(4) Pages: 545-549
• [Presentation] 食肉の加熱調理により生成するグリシドール脂肪酸エステルに関する研究 (2013)
  • Author(s): 平井央子, 島村裕子, 増田修一
  • Organizer: 第106回日本食品衛生学会学術講演会
  • Place of Presentation: 沖縄
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• [Presentation] 食肉中の食中毒菌の分布と電解水による殺菌効果に関する研究 (2013)
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  • Organizer: 第106回日本食品衛生学会学術講演会
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• [Presentation] 食肉中の食中毒菌の分布とその抑制に関する研究 (2013)
  • Author(s): 新家桃香, 島村裕子, 青野博志, 青野盈瓠 , 篠田和代, 佐藤勝浩, 村田容常, 増田修一
  • Organizer: 日本農芸化学会 2013年度大会
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  • Year and Date: 20130325-27
• [Presentation] 食中毒菌の毒素産生および活性を抑制する植物食品の探索 (2013)
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• [Presentation] In vivo コメットアッセイにおける手法間差の検討(2) (2012)
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• [Presentation] 金銀花の抗糖尿病効果に関する研究 (2012)
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  • Organizer: 第17回日本フードファクター学会(JSoFF)学術集会・第 9回日本カテキン学会総会 合同大会
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  • Year and Date: 20121110-11
• [Presentation] グリシドール及びグリシドール脂肪酸エステル類の遺伝毒性に関する研究 (2012)
  • Author(s): 龚 琬, 島村裕子, 米谷民雄, 増田修一
  • Organizer: 第104回日本食品衛生学会学術講演会
  • Place of Presentation: 岡山
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• [Presentation] メイラード反応由来新規変異原性物質 ABAQ の生体内生成に関する研究 (2011)
  • Author(s): 山田昌徳, 島村裕子, 戸塚ゆ加里, クゥリバリ・スレウマン, 田村友佳, 長谷井友尋, 若林敬二, 渡辺徹志, 増田修一
  • Organizer: 日本環境変異原学会第40回大会
  • Place of Presentation: 東京
  • Year and Date: 20111121-22
• [Presentation] 静岡県地場産品におけるアクリルアミドの生成及び遺伝毒性に対する抑制効果(2) (2011)
  • Author(s): 飯尾美沙子, 平野元美, 島村裕子, 中村好志, 米谷民雄, 増田修一
  • Organizer: 第102回日本食品衛生学会学術講演会
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  • Year and Date: 20110929-30
• [Presentation] 静岡県地場産品のアクリルアミドの生成及び遺伝毒性に対する抑制効果 (2011)
  • Author(s): 飯尾美沙子, 平野元美, 増田修一, 米谷民雄, 中村好志
  • Organizer: 日本農芸化学会 2011年度大会
  • Place of Presentation: 京都
  • Year and Date: 20110326-28
• [Remarks]
  • URL: http://sfns.u-shizuoka-ken.ac.jp/foodhygn/index.html