2014 Fiscal Year Final Research Report
Study of combined estrogenic activity of supplements containing isoflavone
| Project/Area Number |
23500965
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Kyoto Women's University (2012-2014)
Kyoto Prefectural University (2011) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIDA Kaoru 京都光華女子大学, 健康科学部, 教授 (10336787)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Keywords | 食品 / 衛生 / 健康食品 / サプリメント / イソフラボン / エストロゲン |
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| Outline of Final Research Achievements |
We investigated the contents of 15 kinds of isoflavone in various supplements containing Pueraria lobata (PL), red clover (RC), Pueraria mirifica (PM), alfalfa or soybean isoflavone (DI) by HPLC. Total isoflavone contents of PL supplements were higher than that of other supplements. PL, RC or PM supplements may be taken with DI supplements. Therefore, the possibility of excessive intake of isoflavone should be considered.
We measured the combined estrogenic activities of plant extracts as supplement materials by a yeast two-hybrid assay. RC extract plus DI extract showed additional estrogenic activity for hERα. It is necessary to take in RC and DI supplements with caution.
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| Free Research Field |
食品安全性学・環境毒性学
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