2013 Fiscal Year Final Research Report
Structural analysis of sphingoglycolipid from Basidiomycota
| Project/Area Number |
23500980
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Soai University |
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Principal Investigator |
MIZUNO seiko 相愛大学, 人間発達学部, その他 (90190652)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIWARA Nagatoshi 帝塚山大学, 現代生活学部, 教授 (80326256)
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| Project Period (FY) |
2011 – 2013
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| Keywords | スフィンゴ糖脂質 / 生理活性 |
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| Research Abstract |
In this study, we found out the synthesis of glycosphingolipids(GSL-1) in Maitake and Enokitake, and reported the structure in detail for the first time. The sugar component of GSL-1 was
assigned to be a glucose. LCB and FA fractions were analyzed by GC and GC/MS, and implied that the main components were C20:1 sphingenine for LCB, and C16:0, 2-OH-C16:0 for FA. Taken together, each GSL-1 of Maitake and Enokitake were same structure and defined as a glucosyl (1-1) ceramide. For biological clarification of the GSLs, the glycolipid fraction containing GSL-1 of Maitake and Enokitake were intraperitoneal injection to mouse. Numbers of peritoneal leukocyte were higher in mouse which intraperitoneal injected glycolipid fraction. From the results, the immunostimulatory effect of the glycolipid of Maitake and Enokitake was suggested.
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Research Products
(13 results)
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[Journal Article] Bacterial sphingo phospholipids containing non fatty acid activate murine macrophages via Toll-like receptor 4 and bacterial clearance2013
Author(s)
Fujiwara, N., S.A. Porcelli, T. Naka, I. Yano, S. Maeda, H. Kuwata, S. Akira, S. Uematsu, T. Takii, H. Ogura, and K. Kobayashi
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Journal Title
Biochim. Biophys. Acta
Volume: 1831 (6)
Pages: 1177-1184
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