2013 Fiscal Year Final Research Report
Safety of weight loss plant material and association of dietary macronutrients
| Project/Area Number |
23500999
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | National Institute of Health and Nutrition |
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Principal Investigator |
UMEGAKI keizo 独立行政法人国立健康・栄養研究所, 情報センター, センター長 (60191920)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 安全性 / ダイエット食品 / 主要栄養素 / 肝薬物代謝酵素 / 相互作用 / ハーブ |
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| Research Abstract |
Coleus forskohlii extract (CFE) standardized to 10% forskolin is a popular herbal ingredient for commercial weight loss dietary supplement, because forskolin has been shown to increase c-AMP accumulation and lipolysis in fat cells. Feeding CFE to mice increased liver weight, induced cytochrome P450(CYP) and fatty liver. CFE attenuated the anticoagulant action of warfarin, and hypoglycemic action of tolbutamide via induction of hepatic CYP2C. Dietary starch potentiated CFE-induced CYP induction. Inductions of CYP and fatty liver by CFE were not due to forskolin, but due to un-identified substances that were soluble in ether.
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