2014 Fiscal Year Final Research Report
Role of p63 in metastasis and therapeutic resistance of bladder cancer
| Project/Area Number |
23501266
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
KOGA Fumitaka 東京医科歯科大学, 医歯(薬)学総合研究科, 非常勤講師 (10285851)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Keywords | 膀胱癌 / 転移 / 治療抵抗性 / ｐ６３ |
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| Outline of Final Research Achievements |
The following findings were obtained in the present study series and reported in international medical journals. (1) Bladder cancer stem cells are resistant to cisplatin and they lose expression of p63 protein, suggesting that loss of p63 is associated with cisplatin resistance. (2) No significant association was obtained between chemoradiation resistance and p63 expression profile in muscle-invasive bladder cancer. (3)Overexpression of erbB2 in bladder cancer is significantly associated with resistance to chemoradiation and bladder cancer death.
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| Free Research Field |
泌尿器腫瘍
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