2013 Fiscal Year Final Research Report
Roles of Lutheran in tumor cell adhesion and migration
| Project/Area Number |
23501270
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MITAKA Toshihiro 札幌医科大学, 医学部, 教授 (50231618)
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| Project Period (FY) |
2011 – 2013
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| Keywords | ラミニン / ルテラン / インテグリン / 免疫グロブリンスーパーファミリー / 細胞接着 / 細胞外マトリックス |
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| Research Abstract |
Lutheran (Lu), an immunoglobulin superfamily transmembrane receptor, is also known as basal cell adhesion molecule (B-CAM). Lu/B-CAM is a specific receptor for laminin alpha5, a subunit of laminin-511 that is a major component of basement membranes in various tissues. Therefore it is likely that the interaction between Lu/B-CAM and laminin alpha5 involves in tumor cell invasion and metastasis. In this study we discovered an antibody that inhibited the binding of Lu/B-CAM to laminin alpha5 and provided mechanistic insight in tumor cell migration on laminin-511. We also showed that Lu/B-CAM released from cell surface was a candidate marker for hepatocellular carcinoma.
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[Journal Article] Absence of post-phosphoryl modification in dystroglycanopathy mouse models and wild-type tissues expressing non-laminin binding form of alpha-dystroglycan2012
Author(s)
Kuga A, Kanagawa M, Sudo A, Chan YM, Tajiri M, Manya H, Kikkawa Y, Nomizu M, Kobayashi K, Endo T, Lu QL, Wada Y, Toda T
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Journal Title
J Biol Chem
Volume: 287
Pages: 9560-9567
DOI
Peer Reviewed
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