2013 Fiscal Year Final Research Report
14-3-3beta-FBI1/Akirin2 complex promotes tumorigenicity and metastasis
| Project/Area Number |
23501271
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
TASHIRO Fumio 東京理科大学, 基礎工学部, 教授 (70089332)
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| Co-Investigator(Kenkyū-buntansha) |
AKIYAMA Hirotada 東京理科大学, 基礎工学部生物工学科, 助教 (40400254)
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| Project Period (FY) |
2011 – 2013
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| Keywords | がん制御因子 / 14-3-3 / FBI1/Akinin2 |
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| Research Abstract |
We previously demonstrated that 14-3-3beta protein promotes cell growth and tumorigenicity of rat K2 hepatocellular carcinoma cells. We identified FBI1/Akirin2 as a binding partner of 14-3-3beta and showed that the complex of these proteins promotes tumorigenicity and metastasis of K2 cells. Based on microarray expression analysis, BCAM and SPARC were identified as the downregulated target genes of the oncogenic 14-3-3beta-FBI1/Akirin2 complex. BCAM and SPARC are suppressive oncoprotein, and that FBI1/Akirin2 is involved in tumorigenicity and metastasis of hepatoma through the downregulation of suppressive oncogenes. Furthermore, we demonstrated that FBI1/Akirin2 performs an oncogenic function in LLC1 Lewis lung carcinoma cells. Although further investigation is required, these results suggest that FBI1/Akirin2 may perform an universal oncogenic function in various cancers.
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[Journal Article] The FBI1/Akirin2 target gene, BCAM, acts as a suppressive oncogene2013
Author(s)
Akiyama H, Iwahana Y, Suda M, Yoshimura A, Kogai H, Nagashima A, Ohtsuka H, Komiya Y, Tashiro F
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Journal Title
PLoS One
Volume: 8(11)
Pages: e78716
DOI
Peer Reviewed
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[Journal Article] The Arf/p53 protein module, which induces apoptosis, down-regulates histone H2AX to allow normal cells to survive in the presence of anti-cancer drugs2013
Author(s)
Atsumi Y, Inase A, Osawa T, Sugihara E, Sakasai R, Fujimori H, Teraoka H, Saya H, Kanno M, Tashiro F, Nakagama H, Masutani M, Yoshioka K
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Journal Title
J. Biol. Chem.
Volume: 288(19)
Pages: 13269-13277
DOI
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[Journal Article] Cancer susceptibility polymorphism of p53 at codon 72 affects phosphorylation and degradation of p53 protein2011
Author(s)
Ozeki C, Sawai Y, Shibata T, Kohno T, Okamoto K, Yokota J, Tashiro F, Tanuma S, Sakai R, Kawase T, Kitabayashi I, Taya Y, Ohki R
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Journal Title
J. Biol. Chem.
Volume: 286(20)
Pages: 18251-18260
DOI
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