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2013 Fiscal Year Final Research Report

Clinical significance of Fatty Acid Binding Protein 5 in hepatocellular carcinoma

Research Project

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Project/Area Number 23501293
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Tumor diagnosis
Research InstitutionHokkaido University

Principal Investigator

YOKOO Hideki  北海道大学, 大学病院, 助教 (70399947)

Co-Investigator(Kenkyū-buntansha) KAMIYAMA Toshiya  北海道大学, 大学院医学研究科, 准教授 (80322816)
NAKANISHI Kazuaki  北海道大学, 大学院医学研究科, 非常勤講師 (80374338)
KAKISAKA Tatsuhiko  北海道大学, 北海道大学病院, 医員 (40583092)
Project Period (FY) 2011 – 2013
Keywords肝細胞癌 / バイオマーカー / E-FABP
Research Abstract

We analyzed the correlation between the expression of FABP5 and malignant behavior of HCC using HCC tissues and cell lines. A total of 243 HCC samples were subjected to immunohistochemistry, and protein expression of FABP5 in HCC cell lines was assessed by Western blot. The intensity of immunostaining in HCC tissues were divided into a strong staining group and a weak staining group. In the strong group, 5-year overall survival rate was 59.5%, compared with 89.9% in the weak group , and 5-year relapse free survival rate in the strong group was 23.7%, compared with 47.2% in the weak group . In vitro, Western blot showed protein expression of highly invasive cell lines was high, while lowly invasive cell was low. The knockdown of FABP5 in highly invasive cell lines also inhibited cell proliferation, migration and invasiveness significantly. FABP5 was closely related with malignancy, and also behaved as a significant prognostic and recurrence factor for HCC patients.

  • Research Products

    (6 results)

All 2014 2013

All Presentation (6 results)

  • [Presentation] 肝細胞癌におけるFABP5 の新規バイオマーカーとしての有用性2014

    • Author(s)
      大畑多嘉宣、横尾英樹
    • Organizer
      第114回日本外科学会定期学術集会
    • Place of Presentation
      京都国際会館・グランドプリンスホテル京都(京都市)
    • Year and Date
      20140403-05
  • [Presentation] Utility of Fatty Acid Binding Protein 5 expression as a recurrence and prognostic factor in hepatocellular carcinoma2013

    • Author(s)
      Takanori Ohata, Hideki Yokoo
    • Organizer
      AASLD Liver Meeting 2013
    • Place of Presentation
      Walter E. Washington Conference Center (WashingtonDC, USA)
    • Year and Date
      20131101-05
  • [Presentation] Utility of FABP5 expression as a recurrence and prognostic factor in hepatocellular carcinoma2013

    • Author(s)
      Takanori Ohata, Hideki Yokoo
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      20131003-05
  • [Presentation] 肝細胞癌における予後再発因子としてのFABP5の有用性について2013

    • Author(s)
      大畑多嘉宣、横尾英樹
    • Organizer
      第24回消化器癌発生学会総会
    • Place of Presentation
      石川県立音楽堂・ホテル日航金沢(金沢市)
    • Year and Date
      20130905-06
  • [Presentation] 肝細胞癌における予後再発因子としてのFABP5発現の意義2013

    • Author(s)
      大畑多嘉宣、横尾英樹
    • Organizer
      第68回日本消化器外科学会総会
    • Place of Presentation
      シーガイアコンベンションセンター(宮崎市)
    • Year and Date
      20130717-19
  • [Presentation] 肝細胞癌における予後再発因子としてのFABP5発現の検討2013

    • Author(s)
      大畑多嘉宣、横尾英樹
    • Organizer
      第113回日本外科学会定期学術集会
    • Place of Presentation
      福岡国際会議場・福岡サンパレス・マリンメッセ福岡(福岡市)
    • Year and Date
      20130411-13

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Published: 2015-07-16  

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