2013 Fiscal Year Final Research Report
Development of new tumor markers based on microRNA expression in urine of the patients with urothelial carcinoma
| Project/Area Number |
23501298
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor diagnosis
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| Research Institution | Kagoshima University |
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Principal Investigator |
enokida hideki 鹿児島大学, 医歯(薬)学総合研究科, 准教授 (80347103)
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| Co-Investigator(Kenkyū-buntansha) |
川上 一盛 鹿児島大学, 医学部・歯学部附属病院, 助教 (00404517)
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| Research Collaborator |
YOSHINO HIROFUMI 鹿児島大学, 医歯学総合研究科, 大学院生
HIDAKA HIDEO 鹿児島大学, 医歯学総合研究科, 大学院生
YAMASAKI TAKESHI 鹿児島大学, 医歯学総合研究科, 大学院生
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| Project Period (FY) |
2011 – 2013
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| Keywords | microRNA / 膀胱癌 / 診断マーカー |
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| Outline of Final Research Achievements |
We developed novel urine markers for detecting urothelial carcinoma. Retrospective examination using 100 bladder cancer, 49 healthy volunteers, and 25 urinary tract infection patients revealed that miR-96 and miR-183 could distinguish cancer from benign disease with good sensitivity and specificity. These miRNAs expressions were well correlated with tumor stage and grade as recurrence free survival of non-muscle invasive blader cancer.
As for prospective examination of the out patients with macroscopic hematuria revealed that miR-X was a promising tumor markers with less false posive affected by macroscopic hematuria.
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| Free Research Field |
総合領域
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