2013 Fiscal Year Final Research Report
Development of tailor-made personalized biomarker using circulating nucleic acids in patients with digestive system cancer
| Project/Area Number |
23501299
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor diagnosis
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
KAZUMA Okamoto 京都府立医科大学, 医学(系)研究科(研究院), 講師 (20285258)
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| Co-Investigator(Kenkyū-buntansha) |
ICHIKAWA Daisuke 京都府立医科大学, 医学研究科, 講師 (20347446)
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| Project Period (FY) |
2011 – 2013
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| Keywords | バイオマーカー / 消化器癌 / 腫瘍マーカー / 個別化医療 / microRNA / 術後管理 |
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| Research Abstract |
This study was conducted to isolate gastric cancer(GC)-associated microRNAs (miR) in plasma on a miR microarray comparing pre- and post-operative paired plasma. Two candidate microRNAs, miR-451 and miR-486, were found to decrease in post-operative plasma, and the levels of both miRs were found to be significantly higher in GC patients than healthy controls. We also compared plasma miR profiles in pre-operative, post-operative, and at the time of recurrence of same GC patients, and isolated three candidate miRs (miR-92a, 93, and 185). All of patients with lymph node recurrences showed miR-185 high expression in their plasma. Further analysis should clarify the origin of extracellular circulating miRs.
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