2014 Fiscal Year Final Research Report
Development of comprehensive geriatric assessment-oriented treatment strategy for elderly cancer patients
Project/Area Number |
23501318
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Clinical oncology
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Research Institution | Fukuoka University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
TAMURA Kazuo 福岡大学, 医学部, 教授 (60145422)
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Project Period (FY) |
2011-04-28 – 2015-03-31
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Keywords | 高齢者 / がん薬物療法 / 包括的機能評価 / 日常生活の質 / 外来化学療法 |
Outline of Final Research Achievements |
Older patients of same chronologic ages differ widely in physical and psychological function. Treatment strategy should be altered according to functional assessments of each patient. We underwent the comprehensive geriatric assessment (CGA), including psychological status, activities of daily living (ADL), instrumental ADL (IADL), nutritional status, comorbidity and cognitive function in patients with newly diagnosed malignant lymphoma. High ages, advanced stages and severe comorbidities were significantly associated with high incidence of treatment discontinuation, while high ages, ADL-dependencies and accumulation of severe comorbidities were significantly associated with low complete remission (CR) rates. ADL-dependency was significantly associated with overall survival. Performance status was not associated with either CR rate or OS. It indicates that CGA is an effective tool for predicting clinical outcomes in elderly patients who received anti-cancer chemotherapy.
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Free Research Field |
臨床腫瘍学、血液内科学
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