2013 Fiscal Year Final Research Report
An analysis of the mechanisms of loss of immune system in T cell induced by p53 gene instability after irradiation at a young age
| Project/Area Number |
23510070
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Risk sciences of radiation/Chemicals
|
|---|
| Research Institution | University of Occupational and Environmental Health, Japan |
|---|
Principal Investigator |
OKAZAKI Ryuji 産業医科大学, 産業生態科学研究所, 教授 (50309960)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OOTSUYAMA Akira 産業医科大学, 医学部, 教育教授 (10194218)
YOSHIDA Yasuhiro 産業医科大学, 医学部, 准教授 (10309958)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | 若年時放射線被曝 / p53 / NF-κB / 炎症 |
|---|
| Research Abstract |
Radio-sensitivity is highest during young age, and radiation effects are different at old age depending on the age at the time of exposure.
In this study, we exposed p53+/- mice to a whole-body dose of 3 Gy at 8, 17, 30 and 41 weeks of age, and evaluated NF-kB and the related genes of the spleen at 56 weeks of age. CDK2, p21, phospho (p)-IKKa, p-IkBa, p-p65, NF-kB and ATP were elevated only in the mice that were given a whole-body dose of 3 Gy at 8 weeks of age. Taken together, irradiation at a young age might elevate NF-kB and ATP at old age. We suggest that the elevation of NF-kB means the continuation of inflammation and is related to the induction of cancer.
|
