2014 Fiscal Year Final Research Report
Variety of histone modifications by arsenic compounds, and the meanings of these modifications.
| Project/Area Number |
23510082
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Keywords | ヒ素化合物 / エピジェネティクス / ヒストン修飾 / 遺伝子誘導 |
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| Outline of Final Research Achievements |
The purpose of this work was to evaluate the modification of histone by arsenic compounds, and to elucidate the meanings of these modifications.
Inorganic arsenite [iAs(III)] induced phosphorylation and methylation of histone H3, and phospho-histone H3 was observed as a punctual signals in specific region. Furthermore, we fund phospho-histone H3 was localized in the promoter region of FOS and EGR1, which were induced by iAs(III). These results suggested that the modification of histone changes chromatin structure and then induces gene expression.
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| Free Research Field |
毒性学
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