2013 Fiscal Year Final Research Report
Developmental neurotoxicity of volatile organic compounds: the evaluation of social behaviors and the developing of biomarkers
| Project/Area Number |
23510084
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Risk sciences of radiation/Chemicals
|
|---|
| Research Institution | University of Occupational and Environmental Health, Japan |
|---|
Principal Investigator |
UENO Susumu 産業医科大学, 産業生態科学研究所, 教授 (00279324)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
FUETA Yukiko 産業医科大学, 産業保健学部, 講師 (10132482)
YOSHIDA Yasuhiro 産業医科大学, 医学部, 准教授 (10309958)
ISHIDAO Toru 産業医科大学, 産業保健学部, 講師 (90212901)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | 1-ブロモプロパン / 揮発性有機化合物 / 胎生期曝露 / 海馬神経回路 / 神経行動 / 飼育環境 / 臭素イオン |
|---|
| Research Abstract |
The purpose of this research project is to evaluate developmental neurotoxicity of volatile organic compounds, and to explore a biomarker which can be applied to an evaluation index for the toxicity. We used model rats which were prenatally exposed to an organic solvent 1-bromopropane (1BP), and as a result, we found that a breeding environment soon after weaning day could affect exploration activity, although it was observed transiently. Additionally, we found that prenatal 1BP-exposure could enhance the development of the stimulation-response relationship in brain neural circuit, which could partly due to an accumulation of bromine ion in brain.
|
