Fabrication of sensitive nano-probes based on gold nanoparticles formed by thermal stimuli

2014 Fiscal Year Final Research Report

• Project/Area Number: 23510123
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Nanomaterials/Nanobioscience
• Research Institution: Utsunomiya University
• Principal Investigator: UEHARA Nobuo 宇都宮大学, 工学(系)研究科(研究院), 准教授 (50203469)
• Co-Investigator(Renkei-kenkyūsha): MORITA Takeshi (80332633)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: 金ナノ粒子 / 熱応答性高分子 / センシング / プローブ

Outline of Final Research Achievements

This research aims to elucidate a mechanism of fusion growth of gold nanoparticles conjugated with thermoresponsive polymers induced by thermal stimuli and to develop chemical probes measuring bio-related molecules based on the mechanism.
Elucidation of a mechanism of fusion growth of gold nanoparticles:We have found that 5-6 nm gold nanoparticles conjugated with thermoresponsive polymers fuse to grow as a result of being heated followed by being cooled. Some parameters such as temperature of a solution, heating time, types of inhibitors, and concentration of the inhibitors were in terms of TEM observation, spectrophotometry, dynamic light scattering, and small angle X-ray scattering to elucidate the mechanism. As a result, shrinkage of chains of the thermoresponsive polymers induced by heating a solution leaded to contact of the nanoparticles, resulting in the growth of the nanoparticles.

Free Research Field

分析化学