2014 Fiscal Year Final Research Report
Fabrication of sensitive nano-probes based on gold nanoparticles formed by thermal stimuli
Project/Area Number |
23510123
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Nanomaterials/Nanobioscience
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Research Institution | Utsunomiya University |
Principal Investigator |
UEHARA Nobuo 宇都宮大学, 工学(系)研究科(研究院), 准教授 (50203469)
|
Co-Investigator(Renkei-kenkyūsha) |
MORITA Takeshi (80332633)
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Project Period (FY) |
2011-04-28 – 2015-03-31
|
Keywords | 金ナノ粒子 / 熱応答性高分子 / センシング / プローブ |
Outline of Final Research Achievements |
This research aims to elucidate a mechanism of fusion growth of gold nanoparticles conjugated with thermoresponsive polymers induced by thermal stimuli and to develop chemical probes measuring bio-related molecules based on the mechanism. Elucidation of a mechanism of fusion growth of gold nanoparticles:We have found that 5-6 nm gold nanoparticles conjugated with thermoresponsive polymers fuse to grow as a result of being heated followed by being cooled. Some parameters such as temperature of a solution, heating time, types of inhibitors, and concentration of the inhibitors were in terms of TEM observation, spectrophotometry, dynamic light scattering, and small angle X-ray scattering to elucidate the mechanism. As a result, shrinkage of chains of the thermoresponsive polymers induced by heating a solution leaded to contact of the nanoparticles, resulting in the growth of the nanoparticles.
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Free Research Field |
分析化学
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