2013 Fiscal Year Final Research Report
Development of Innovative Targeting Artificial pulmonary surfactant preparations by Nanomedicine
| Project/Area Number |
23510134
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nanomaterials/Nanobioscience
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| Research Institution | Nagasaki International University |
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Principal Investigator |
SHIBATA Osamu 長崎国際大学, 薬学部, 教授 (10117129)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAHARA Hiromichi 長崎国際大学, 薬学部薬学科, 講師 (00513235)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 表面・界面物性 / 肺サーファクタント / ナノ医薬品 / インテリジェント・ナノ材 料 / ラングミュアー単分子膜 / ナノ機能材料 / 呼吸窮迫症候群 / 偏光変調赤外反射吸収法 |
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| Research Abstract |
The model peptide in artificial pulmonary surfactant (PS) changes its secondary structure from alpha-helix to beta-sheet upon lateral compression. However, in the presence of anionic lipids such as phosphatidylglycerol and palmitic acid, the conversion of the structure is found to prevent from the spectroscopic aspect. And fluorinated compound additive in PS also very effective for PS preparation. The mechanism and function of PS across the interface have been elucidated from the thermodynamic, morphological, and spectroscopic perspectives.
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