2013 Fiscal Year Final Research Report
The role of testicular mono-ADP-ribosylation in men with idiopathic infertility
| Project/Area Number |
23510242
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical genome science
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| Research Institution | The University of Tokushima |
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Principal Investigator |
TAJIMA Atsushi 徳島大学, ヘルスバイオサイエンス研究部, 准教授 (10396864)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 遺伝子相互作用解析 / 遺伝リスク / 男性不妊症 |
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| Research Abstract |
ART3 (ADP-ribosyltransferase 3) have been identified as a susceptibility gene for non-obstructive azoospermia (NOA) in humans. The objective of this study was to reveal a molecular and genetic basis for further understanding of pathophysiological roles of testicular ART3 involved in male infertility. (1) A proteomic analysis indicated that ART3 directly interacted with various proteins, some of which were expressed in human testes, and involved in spermatogenesis. (2) Case-control genetic association studies in Japanese populations demonstrated three NOA susceptibility loci, one of which contained a family gene of the ART3-interacting proteins. Thought the proteomic and genetic analyses, we identified promising candidate genes which might have roles in ART3-dependent regulation of spermatogenesis in humans.
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Research Products
(16 results)
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[Journal Article] Estrogen promotes Leydig cell engulfment by macrophages in male infertility2014
Author(s)
Yu W, Zheng H, Lin W, Tajima A, Zhang Y, Zhang X, Zhang H, Wu J, Han D, Rahman NA, Korach KS, Gao GF, Inoue I, Li X
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Journal Title
J Clin Invest
Volume: 24
Pages: 2709-2721
DOI
Peer Reviewed
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[Journal Article] Meta-analyses of blood homocysteine levels for gender and genetic association studies of the MTHFR C677T polymorphism in schizophrenia2014
Author(s)
Nishi A, Numata S, Tajima A, Kinoshita M, Kikuchi K, Shimodera S, Tomotake M, Ohi K, Hashimoto R, Imoto I, Takeda M, Ohmori T
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Journal Title
Schizophr Bull
Volume: (in press)
DOI
Peer Reviewed
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[Journal Article] A nonsynonymous variant of IL1A is associated with endometriosis in Japanese population2013
Author(s)
Hata Y, Nakaoka H, Yoshihara K, Adachi S, Haino K, Yamaguchi M, Nishikawa N, Kashima K, Yahata T, Tajima A, Watanabe A, Akira S, Hosomichi K, Inoue I, Tanaka K
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Journal Title
J Hum Genet
Volume: 58
Pages: 517-520
DOI
Peer Reviewed
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[Journal Article] High-risk ovarian cancer based on 126-gene expression signature is uniquely characterized by downregulation of antigen presentation pathway2012
Author(s)
Yoshihara K, Tsunoda T, Shigemizu D, Fujiwara H, Hatae M, Masuzaki H, Katabuchi H, Kawakami Y, Okamoto A, Nogawa T, Matsumura N, Udagawa Y, Saito T, Itamochi H, Takano M, Miyagi E, Sudo T, Ushijima K, Iwase H, Seki H, Terao Y, Enomoto T, Mikami M, Akazawa K, Tsuda H, Moriya T, Tajima A, Inoue I, Tanaka K for The Japanese Serous Ovarian Cancer Study Group
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Journal Title
Clin Cancer Res
Volume: 18
Pages: 1374-1385
DOI
Peer Reviewed
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[Journal Article] Identification of independent risk loci for Graves' disease within the MHC in the Japanese population2011
Author(s)
Nakabayashi K, Tajima A, Yamamoto K, Takahashi A, Hata K, Takashima Y, ]Koyanagi M, Nakaoka H, Akamizu T, Ishikawa N, Kubota S, Maeda S, Tsunoda T, Kubo M, Kamatani N, Nakamura Y, Sasazuki T, Shirasawa S
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Journal Title
J Hum Genet
Volume: 56
Pages: 772-778
DOI
Peer Reviewed
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[Journal Article] A systems genetics approach provides a bridge from discovered genetic variants to biological pathways in rheumatoid arthritis2011
Author(s)
Nakaoka H, Cui T, Tajima A, Oka A, Mitsunaga S, Kashiwase K, Homma Y, Sato S, Suzuki Y, Inoko H, Inoue I
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Journal Title
PLoS ONE
Volume: 6
Pages: e25389
DOI
Peer Reviewed
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