2013 Fiscal Year Final Research Report

prevention of gastric carcinogenesis based on gender specific medicine

Research Project

Project/Area Number	23510346
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Gender
Research Institution	University of Fukui
Principal Investigator	OHTANI Masahiro 福井大学, 医学部, 助教 (20372500)
Project Period (FY)	2011 – 2013
Keywords	ラロキシフェン / 胃癌 / ヘリコバクターピロリ / エストロゲン
Research Abstract	Female hormone may have a protective role against gastric carcinogenesis. We examined the effect of raloxifene, which is selective estrogen receptor modulator, on gastric carcinogenesis using INS-GAS mice. Male INS-GAS mice were divided into 4 groups, including controls group, control RAL group, H. pylori infected group and H. pylori infected RAL groups. H. pylori infected mice showed severe gastritis compared to uninfected mice. Histopathology of gastritis in H. pylori infected RAL groups were attenuated inflammation and dysplasia compared to those in H. pylori infected groups. The mRNA levels of RAL group were significantly lower than those of controls groups. Raloxifene may have a suppressive effect on gastric carcinogenesis in INS-GAS mice.