Radiochemical study on effective nuclide probes localized in nasal cavity and tumor tissues, and given high energy transfer on site

2014 Fiscal Year Final Research Report

• Project/Area Number: 23550072
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Inorganic chemistry
• Research Institution: Kanazawa University
• Principal Investigator: AMANO Ryohei 金沢大学, 保健学系, 教授 (30111769)
• Co-Investigator(Kenkyū-buntansha): WASHIYAMA Kohshin 金沢大学, 保健学系, 助教 (80313675) ; MIYATI Toshiaki 金沢大学, 保健学系, 教授 (80324086) ; SHIGA Hideaki 金沢医科大学, 医学部, 准教授 (80436823)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: 高ＬＥＴ核種 / 壊変系列 / アルファ核種 / 内部被ばく線量 / エネルギー付与 / 鼻腔 / 腫瘍

Outline of Final Research Achievements

To assess a radiation energy trannsfer to olfactory bulb from 201Tl localized in nasal cavity, a new site informatic index of nasal cavity and right/left olfactory bulb was given on a digital phantom, Digimouse, to use Monte Carlo simulation for MIRD internal dose computation. And to compare the energy transfers to tumor tissue by alpha-rays emitted among various heavy nuclides and their chemicals localized at the same place, 227Th and 223Ra in the actinium series, and 225Ac in the neptunium series were focused in terms of labeling procedure of their compounds, and observation of localizing in tumor tissue, were discussed by compareing the isotopes(equal Z nuclides) in uranium series and thorium series.

Free Research Field

化学