2013 Fiscal Year Final Research Report
Detection of trace amount of toxic heavy metal ions in environmental and biological samples with highly sensitive and specific fluorescent probes
| Project/Area Number |
23550077
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Inorganic chemistry
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| Research Institution | Nara Women's University |
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Principal Investigator |
MIKATA Yuji 奈良女子大学, 自然科学系, 准教授 (10252826)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 分子認識 / 蛍光プローブ / 重金属 / 生物無機化学 / キノリン / イソキノリン / 亜鉛 / カドミウム |
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| Research Abstract |
Highly sensitive, cell-permeable fluorescent probes for specific metal ions have been developed. In our probe design, metal binding site and fluorescent moiety are combined in a molecule. The synthesized heavy metal targeted fluorescent probe was evaluated extra- and intracellular conditions.
By careful design of the ligand scaffolds, several fluorescent probes that exhibit specific response for zinc, cadmium, and mercury have been developed. The present results provide an important roadmap for designing future fluorescent probes.
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[Journal Article] 8-TQEN (N, N, N', N'-tetrakis- (8-quinolylmethyl)ethylenediamine) Analogs as Fluorescent Cadmium Sensors : Strategies to Enhance Cd^<2+>-Induced Fluorescence and Cd^<2+>/Zn^<2+> Selectivity2014
Author(s)
Y. Mikata, A. Takekoshi, A. Kizu, Y. Nodomi, M. Aoyama, K. Yasuda, S. Tamotsu, H. Konno and S. C. Burdette
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Journal Title
RSC Advances
Volume: 4(25)
Pages: 12849-12856
DOI
Peer Reviewed
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[Journal Article] Syntheses, characterization, and antitumor activity of Pt(II) and Pd(II) complexes with sugar conjugated triazole ligands2012
Author(s)
S. Yano, H. Ohi, M. Ashizaki, M. Obata, Y. Mikata, R. Tanaka, T. Nishioka, I. Kinoshita, Y. Sugai, I. Okura, S. Ogura, J. A. Czaplewska, M. Gottschaldt, U. S. Schubert, T. Funabiki, K. Morimoto, and M. Nakai
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Journal Title
Chemistry & Biodiversity
Volume: 9(9)
Pages: 1903-1915
DOI
Peer Reviewed
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