2013 Fiscal Year Final Research Report
Allylic and propargylic substitutions using the picolinoxy leaving group and application to organic synthesis
| Project/Area Number |
23550119
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | アリル化反応 / 銅試薬 / アセチレン銅試薬 / ピコリン酸アリルエステル / リン酸アリルエステル / 第4級炭素構築 / シクロバクチオール / ジャスモン酸 |
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| Research Abstract |
Allylic substitution of secondary allylic picolinates with copper reagents were investigated to establish methods for: (1) construction of quaternary carbon center; (2) synthesis of anti inflammatory cyclobakuchiols; (3) synthesis of trans 2,6-disubstituted cyclohexanones; (4) introduction of acetylene on a cyclopentane ring; (5) Pd-catalyzed allylic substitution of 1,3-disubstituted secondary allylic esters with ketone enolates.
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