2013 Fiscal Year Final Research Report
Size controlled preparation of functional gold nanoparticles using micelles of reductive-stabilizer
| Project/Area Number |
23550160
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional materials chemistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KURAWAKI Jun-ichi 鹿児島大学, 理工学研究科, 教授 (10170078)
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| Project Period (FY) |
2011 – 2013
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| Keywords | ナノ粒子 / ミセル / シュガーボール / カルバ糖 |
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| Research Abstract |
We have developped a new preparation method of gold nanoparticles (AuNps) using amphipathic alkylaminobenzenthiols and alkylsulfanylanilines as reductive stabilizers (RS) that reduce Au3+ to AuNps and spontaneously stabilize the resulting AuNps by coordination with their thiol or amino group. Since the reduction reaction proceeds inside of the micelles of RS, the shape and stability of the resulting AuNp were controlled by the structure of RS. By using a mixture of these compounds, the AuNps covered with different type of compounds can be prepared.
The AuNps covered with sugar molecules were easily prepared with the sugar-derived RS. The resulting sugar-AuNps showed specific and reversible interaction with concanavalin A, a carbohydrate-binding protein. Asymmetric synthesis of four biologically active sugar mimics has also been accomplished. We are planning to introduce them to the RS to give biologically active AuNps.
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Research Products
(22 results)
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[Journal Article] The bioassay-guided isolation of growth inhibitors of adult T-cell leukemia (ATL), from the Jamaican plant Hyptis verticillata, and NMR characterization of hyptoside2012
Author(s)
T. Hamada, Y. White, M. Nakashima, Y. Oiso, M. Fujita, H. Okamura, T. Iwagawa, N. Arima
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Journal Title
Molecules
Volume: Vol. 17, No. 8
Pages: 9931-9938
DOI
Peer Reviewed
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