2013 Fiscal Year Final Research Report
Discrimination of Biological Signals from Dimeric Heteroreceptors
| Project/Area Number |
23550194
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemistry related to living body
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| Research Institution | Saga University |
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Principal Investigator |
KODAMA HIROAKI 佐賀大学, 工学(系)研究科(研究院), 教授 (80205418)
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| Co-Investigator(Kenkyū-buntansha) |
OSADA Satoshi 佐賀大学, 工学系研究科, 准教授 (50284609)
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| Project Period (FY) |
2011 – 2013
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| Keywords | シグナル伝達 / 生体分子 / 生理活性 / 活性酸素 / ダイマー |
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| Research Abstract |
Many G-protein coupled receptors exist as homo-dimers and heterodimers, but also that their dimeric assembly could have important functional roles. To understand the structure and biological roles of dimeric states of formyl peptide receptors, dimeric peptides with subtype selective ligands were synthesized. From the results of biological assays, dimers play a role in binding to the two distinct binding sites.
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