2013 Fiscal Year Final Research Report
Studies on the introduction of transition-metal compounds into the antigen-combining site of tailor-made artificial enzyme (catalytic antibody)
| Project/Area Number |
23550196
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Chemistry related to living body
|
|---|
| Research Institution | Osaka Prefecture University |
|---|
Principal Investigator |
TSUMURAYA Takeshi 大阪府立大学, 理学(系)研究科(研究院), 准教授 (00372855)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
FUJII Ikuo 大阪府立大学, 理学系研究科, 教授 (70189984)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | 酵素 / モノクローナル抗体 / 抗体酵素 / 免疫学 / タンパク質 / 分子認識 / 生体分子 / 人工酵素 |
|---|
| Research Abstract |
In this study we have developed methods for the introduction of transition metal compounds as cofactors into the antigen-combining site to function as metal enzymes. Because transition metal catalysis catalyzes a variety of chemical transformations, the introduction of a transition metal into the antigen-combining site widen the versatility of antibody catalysts. We have studied two methods to introduce the transition metal to the antigen-combining site, (1) immunization of the transition-state analog which contains transition metal compounds, and (2) introduction of transition metal containing artificial cofactors into the antigen-combining site by using the technique of holoabzyme.
|
Research Products
(31 results)
