2013 Fiscal Year Final Research Report
Development of Environmentally-responsive Polymer Micelles Comprising of Molecular Assembly beta-Glucans with Physiological Activities and Their Medical Evolution
| Project/Area Number |
23550199
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemistry related to living body
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | β－グルカン / キトサン / カードラン / ヨウ素錯体 / 高分子ミセル / 環境応答性 / 薬物キャリヤー |
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| Research Abstract |
Beta-glucans such as chitosan and curdlan have an effective physiological activity. However, a significant drawback of insolubility in neutral water exists for the practical use of their beta-glucans. In order to develop promising medical-nanomaterials working as drug carrier with their beta-glucans involved in overcoming the drawback, we have intended the graft (g) and block (b) type-copolymerization of their beta-glucans with hydrophilic and biocompatible polymers, polyethylene glycol and temperature-responsive poly(N-isopropylacrylamide). As a result, some g- and b-type copolymers soluble in neutral aqueous solution were succeed to be synthesized, and then, the molecular assembly complexation of the copolymers with iodine gave rise to assume environmentally-responsive nano-particles with a size of ca. 50-100 nm, containing iodine in internal aggregated-core. Consequently, the nano-particles comprising of the beta-glucans and iodine was expected to be a promising drug-carrier.
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Research Products
(14 results)
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[Journal Article] Eukaryotic Translation Elongation Factor 1A Induces Anoikis by Triggering Cell Detachment2012
Author(s)
K. Itagaki, T. Naito, R. Iwakiri, M. Haga, S. Miura, Y. Saito, T. Owaki, S. Kamiya, T. Iyoda, H. Yajima, S. Iwashita, S. Ejiri, and F. Fukai
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Journal Title
J. Biol. Chem.
Volume: 287
Pages: 16037-16046
Peer Reviewed
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