2013 Fiscal Year Final Research Report
Alignment of ferritins and their derivatives along self-assembled peptide nanoarchitecture
| Project/Area Number |
23550200
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemistry related to living body
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| Research Institution | Ryukoku University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | ペプチド / 自己集合化 / フェリチン |
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| Research Abstract |
Ferritin is a spherical and iron-preservation protein to control iron ion concentration in biosystems. The inner and outer diameters of ferritin shell are about 7 and 12 nm, respectively. In addition, the internal cavity takes various metal particles. Using this property, synthesis of nanoperticles with narrow size distribution is performed to develop a new-type electronic device. However, photolithography is necessary to align ferritins within a nano-scaled area. Meanwhile, peptides form self-assembled nanoarchitechtures depending on their amino acid sequences. If ferritins are aligned along self-assembled peptide nanoarchitechtures, it is possible to realize low cost, simple and easy production of ferritin-based nanodevices. We designed and synthesized self-assembled beta-sheet-forming peptide fibrous formations and successfully aligned ferritins and their derivatives along the peptide nanofibers even in a low density.
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