Invention of Polymeric Hollow Nanoparticles using Shell-crosslinked Polymer Micelles as Precursors and Their Application

2013 Fiscal Year Final Research Report

• Project/Area Number: 23550248
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Polymer/Textile materials
• Research Institution: The University of Kitakyushu
• Principal Investigator: AKIBA Isamu 北九州市立大学, 国際環境工学部, 教授 (80282797)
• Project Period (FY): 2011 – 2013
• Keywords: 高分子ミセル / 両親媒性ブロック共重合体 / 小角X線散乱

Research Abstract

In this study, invention of polymeric hollow nano particles was examined by using shell-crosslinked polymer micelles composed of amphiphilic block copolymers having an alkoxyamine group, which is easily cleaved by heating, between hydrophilic and hydrophobic chains.
Small-angle X-ray scattering (SAXS) measurements indicated that shell-crosslinked polymer micelles composed of amphiphilic poly(acrylic acid)-block-polystyrene were successfully prepared. In addition, by heating the aqueous solution of the resulting shell-crosslinked micelles in the presence of large amount toluene, polymeric hollow nano particles were formed due to cleavage of alkoxyamine connections between hydrophobic and hydrophilic chains, and transport of hydrophobic polystyrenes to toluene phase. Therefore, it was concluded shell-crosslinked polymer micelle having alkoxyamine between hydrophobic and hydrophilic chains is an excellent precursor to prepare polymeric hollow nano particles.

Research Products

• [Journal Article] Study of the Internal Structure of Polymer Micelles by Anomalous Small-angle X-ray Scattering at Two Edges (2013)
  • Author(s): Sakou, M.; Takechi, A.; Murakami, S.; Sakurai, K.; Akiba, I.
  • Journal Title: J. Appl. Cryst. Volume: 46 Pages: 1407-1413
  • Peer Reviewed
• [Journal Article] Access to Different Nanostructures via Self-Assembly of Thiourea-Containing PEGylated Amphiphiles (2013)
  • Author(s): Venkataraman, S.; Chowdhury, Z. A.; Lee, A. L.; Tong, Y. W.; Akiba, I.; Yang, Y. Y.
  • Journal Title: Macromol. Rapid Commun. Volume: 34 Pages: 652-658
  • Peer Reviewed
• [Journal Article] Hydrophobic Molecules Infiltrating into the Poly(ethylene glycol) Domain of the Core/Shell Interface of a Polymeric Micelle : Evidence Obtained with Anomalous Small-Angle X-ray Scattering (2013)
  • Author(s): Sanada, Y.; Akiba, I.; Sakurai, K.; Shiraishi, K.; Yokoyama, M.; Mylonas, E.; Ohta, N.; Yagi, N.; Shinohara, Y.; Amemiya, Y.
  • Journal Title: J. Am. Chem. Soc. Volume: 135 Pages: 2574-2582
  • Peer Reviewed
• [Journal Article] Anomalous Small-Angle X-ray Scattering Study of Structure of Polymer Micelles Having Bromines in Hydrophobic Core (2012)
  • Author(s): Akiba, I.; Takechi, A.; Sakou, M.; Handa, M.; Shinohara, Y.; Amemiya, Y.; Yagi, N.; Sakurai, K.
  • Journal Title: Macromolecules Volume: 45 Pages: 6150-6157
  • Peer Reviewed
• [Presentation] 放射光で見る高分子ミセル内部における低分子量化合物の空間分布 (2014)
  • Author(s): 中西亮輔,木下雅貴,櫻井和朗,秋葉勇
  • Organizer: 第63回高分子年次大会
  • Place of Presentation: 名古屋
  • Year and Date: 2014-05-29
• [Presentation] 異なる寸水鎖を持つブロック共重合体からなる高分子複合体のpH応答性 (2014)
  • Author(s): 中島沙理,木下雅貴,秋葉勇
  • Organizer: 第63回高分子年次大会
  • Place of Presentation: 名古屋
  • Year and Date: 2014-05-29
• [Presentation] 両親媒性AnB型ポリマーの会合構造 (2013)
  • Author(s): 釘本大資,秋葉勇
  • Organizer: 第62回高分子討論会
  • Place of Presentation: 金沢
  • Year and Date: 2013-09-12
• [Presentation] 小角X線異常散乱法による高分子ナノ粒子の内部構造解析 (2013)
  • Author(s): 秋葉勇,木下雅貴,真田雄介,櫻井和朗
  • Organizer: 第62回高分子討論会
  • Place of Presentation: 金沢
  • Year and Date: 2013-09-12
• [Presentation] SAXS、FFF-MALSを用いたAB3型ブロックコポリマーの構造解析 (2013)
  • Author(s): 坂本俊介,真田雄介,秋葉勇,高田斗志彦,櫻井和朗
  • Organizer: 第62回高分子討論会
  • Place of Presentation: 金沢
  • Year and Date: 2013-09-11
• [Presentation] 小角X線異常散乱によるpH応答性ミセルの構造変化の追跡 (2013)
  • Author(s): 木下雅貴,大倉彩,櫻井和朗,秋葉勇
  • Organizer: 第62回高分子年次大会
  • Place of Presentation: 京都
  • Year and Date: 2013-05-31
• [Presentation] ポリエチレン/ポリエチレングリコールブロック共重合体の構造解析 (2013)
  • Author(s): 坂本俊介,真田雄介,秋葉勇,高田斗志彦,櫻井和朗
  • Organizer: 第62回高分子年次大会
  • Place of Presentation: 京都
  • Year and Date: 2013-05-30
• [Presentation] 小角X線異常散乱を用いた両親媒性高分子の会合構造解析 (2012)
  • Author(s): 秋葉勇,酒匂恵,武智敦郎,櫻井和朗
  • Organizer: 第61回高分子討論会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-09-21
• [Presentation] Structural Analysis of Poly(4-vinylphenol)-block-poly(4-br omostyrene) Micelle with Anomalous Small-angle X-ray Scattering (2012)
  • Author(s): Sakou, M.; Takechi, A.; Sakurai, K.; Akiba, I.
  • Organizer: 第61回高分子年次大会
  • Place of Presentation: 横浜
  • Year and Date: 2012-05-31
• [Presentation] Strucural Analysis for Micelle of Cationic Lipid Bromine Modified with Anomalous Small X-ray Scattering (2012)
  • Author(s): Sanada, Y.; Iino, C.; Akiba, I.; Yagi, N.; Shinohara, Y.; Amemiya, Y.; Sakurai, K.
  • Organizer: 第61回高分子年次大会
  • Place of Presentation: 横浜
  • Year and Date: 2012-05-31