The study of the generating and affecting of the high intensity burst pulse electromagnetic wave for the cancer treatment method using the ultra-short pulsed high electric field

2013 Fiscal Year Final Research Report

• Project/Area Number: 23560312
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Power engineering/Power conversion/Electric machinery
• Research Institution: Yamagata University
• Principal Investigator: MINAMITANI Yasushi 山形大学, 理工学研究科, 准教授 (10323172)
• Project Period (FY): 2011 – 2013
• Keywords: がん治療 / アポトーシス / 超短パルス高電界 / パルス電磁波 / SOSダイオード

Research Abstract

This work focuses on the design of a compact high power pulsed electromagnetic wave generator using a nanosecond pulsed power generator to apply a high-intensity electric field for a cancer treatment. In previous study, since the output voltage waveform of the pulsed power generator was damping oscillation, the duration of the burst pulse was under 100 ns. So the generator uses a magnetic switch instead of the gap switch and uses a SOS diode with current cutoff time of nanoseconds. The cluster pulse has 6 burst pulses that continue for 3000 ns. And the effect of frequency of burst pulse high electric field on HeLa cells has been clarified.

Research Products

• [Journal Article] Development of a High Frequency Cluster Burst Pulse Generator Based on a SOS Diode Using Transmission Line Resonant for Bioelectrics Applications (2014)
  • Author(s): Daisuke Matsukubo, Yasushi Minamitani
  • Journal Title: 2013 IEEE Pulsed Power Conference Record Volume: (CD-ROM)
• [Journal Article] Development of a RF burst pulse generator using a non-linear transmission line for cancer treatment (2013)
  • Author(s): Yuichi Abe, Yasushi Minamitani
  • Journal Title: Proceedings of the IEEE 2012 Power Modulator Conference Volume: (CD-ROM)
  • Peer Reviewed
• [Journal Article] Development of a Cluster Burst Pulse Generator Based on a SOS Diode Switch for Bioelectrics Applications (2012)
  • Author(s): Takashi Toyooka, Yasushi Minamitani
  • Journal Title: Proceedings of the IEEE 2011 Pulsed Power Conference Volume: (CD-ROM)
• [Presentation] The dependence of protein expression level in HeLa cells on the frequency of high frequency burst pulse high electric field (2012)
  • Author(s): Yasushi Minamitani, Yoshie Kuramochi, Takashi Toyooka, Kazuki Shinagawa, Kazunori Mitsutake, Misako Yano, Masaya, Morotomi, Sunao Katsuki, Hidenori Akiyama
  • Organizer: 2012 International Bioelectrics Symposium
  • Place of Presentation: 熊本市,KKRホテル熊本
  • Year and Date: 2012-09-07
• [Presentation] Development of a High Frequency Cluster Burst Pulse Generator Based on a SOS Diode for Cancer Treatment (2012)
  • Author(s): Daisuke Matsukubo, Takashi Toyooka, Yasushi Minamitani
  • Organizer: 2012 International Bioelectrics Symposium
  • Place of Presentation: 熊本市,KKRホテル熊本
  • Year and Date: 2012-09-07
• [Presentation] Development of a RF Burst Pulse Generator Using a Nonlinear Transmission Line for Cancer Treatment (2012)
  • Author(s): Yuichi Abe, Yasushi Minamitani
  • Organizer: 2012 International Bioelectrics Symposium
  • Place of Presentation: 熊本市,KKRホテル熊本
  • Year and Date: 2012-09-07