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2013 Fiscal Year Final Research Report

A Study on Anesthesia Control Considering Time Variabllity of Kinetics and Effect of Anesthetic Drugs

Research Project

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Project/Area Number 23560527
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Control engineering
Research InstitutionKyoto University

Principal Investigator

FURUTANI EIKO  京都大学, 工学(系)研究科(研究院), 准教授 (40219118)

Project Period (FY) 2011 – 2013
Keywords麻酔制御 / 時変モデル / propofol / remifentanil / aepEX / 鎮痛度 / 鎮痛侵害受容指数
Research Abstract

In this research, we have studied an anesthesia control system considering time variability of kinetics and effect of anesthetic drugs during surgery. First, we developed a pharmacokinetic model with a time-varying clearance, which represents time variability of hypnotic effect of propofol, an anesthetic drug. Utilizing the model, hypnosis can be kept properly by maintaining estimated effect-site concentration of propofol at a constant level. Second, we confirmed that Analgesia/Nociception Index is more effective as an analgesia index than existing indices, and constructed a hypnosis and analgesia control method considering interaction of propofol and remifentanil, an analgesic drug. Simulation results show that the developed control method can maintain hypnosis and analgesia appropriately if sufficient analgesia is achieved at the beginning of surgery.

  • Research Products

    (11 results)

All 2014 2013 2012 2011 Other

All Presentation (10 results) Remarks (1 results)

  • [Presentation] 鎮痛度指標Analgesia/Nociception Indexを用いた鎮痛度制御の検討2014

    • Author(s)
      谷口将大朗,大田敏嗣,古谷栄光,廣田喜一,武田敏宏,白神豪太郎,福田和彦
    • Organizer
      第58回システム制御情報学会研究発表講演会
    • Place of Presentation
      京都テルサ(京都府)
    • Year and Date
      2014-05-23
  • [Presentation] Anesthesia control based on minimum drug concentrations for keeping appropriate hypnosis and analgesia2013

    • Author(s)
      Eiko Furutani, Yutaka Nakayama, Takehiro Takeda, and Gotaro Shirakami
    • Organizer
      計測自動制御学会ライフサイエンス部門シンポジウム
    • Place of Presentation
      慶応義塾大学(東京都)
    • Year and Date
      2013-09-14
  • [Presentation] Hypnosis control based on the minimum concentration of anesthetic drug for maintaining appropriate hypnosis2013

    • Author(s)
      Eiko Furutani, Yuki Nishigaki, Chiaki Kanda, Takehiro Takeda, and Gotaro Shirakami
    • Organizer
      35th Annual International Conference of IEEE Engineering in Medicine and Biology
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2013-07-05
  • [Presentation] 麻酔薬に対する応答の時変性を考慮した鎮静度維持のための最小麻酔薬濃度に基づく鎮静度制御システムの改良2013

    • Author(s)
      酒井智衣,中山裕,古谷栄光,武田敏宏,白神豪太郎
    • Organizer
      第57回システム制御情報学会研究発表講演会
    • Place of Presentation
      兵庫県民会館(兵庫県)
    • Year and Date
      2013-05-17
  • [Presentation] 複数の鎮痛度指標に基づく麻酔鎮痛度制御法の検討2013

    • Author(s)
      大田敏嗣,黒澤拓人,古谷栄光,廣田喜一,武田敏宏,白神豪太郎,福田和彦
    • Organizer
      第57回システム制御情報学会研究発表講演会
    • Place of Presentation
      兵庫県民会館(兵庫県)
    • Year and Date
      2013-05-17
  • [Presentation] 麻酔薬投与時間による生体の特性変化を考慮した鎮静度制御システム2012

    • Author(s)
      中山裕,古谷栄光,白神豪太郎,武田敏宏
    • Organizer
      第55回自動制御連合講演会
    • Place of Presentation
      京都大学(京都府)
    • Year and Date
      2012-11-17
  • [Presentation] 麻酔鎮痛度制御のための鎮痛度指標の検討2012

    • Author(s)
      古谷栄光,黒澤拓人,廣田喜一,白神豪太郎,武田敏宏,福田和彦
    • Organizer
      第55回自動制御連合講演会
    • Place of Presentation
      京都大学(京都府)
    • Year and Date
      2012-11-17
  • [Presentation] 鎮痛度指標aepEXより算出したプロポフォール最小効果部位濃度の経時的変化2012

    • Author(s)
      武田敏宏,古谷栄光,中山裕,白神豪太郎
    • Organizer
      第19回日本静脈麻酔学会
    • Place of Presentation
      札幌医科大学(北海道)
    • Year and Date
      2012-09-29
  • [Presentation] 聴覚誘発電位に基づく鎮静度指標aepEXを用いた鎮静度制御システムの改良2012

    • Author(s)
      神田千秋,古谷栄光,白神豪太郎,武田敏宏
    • Organizer
      第56回システム制御情報学会研究発表講演会
    • Place of Presentation
      京都テルサ(京都府)
    • Year and Date
      2012-05-23
  • [Presentation] 鎮静度指標aepEXを用いた鎮静度自動制御法2011

    • Author(s)
      古谷栄光,西垣勇輝,武田敏宏,白神豪太郎
    • Organizer
      第18回日本静脈麻酔学会
    • Place of Presentation
      京都リサーチパーク(京都府)
    • Year and Date
      2011-11-26
  • [Remarks]

    • URL

      http://turbine.kuee.kyoto-u.ac.jp/~furutani/kakenhi/kaken_23560527

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Published: 2015-07-16  

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