2013 Fiscal Year Final Research Report
A Study on Anesthesia Control Considering Time Variabllity of Kinetics and Effect of Anesthetic Drugs
| Project/Area Number |
23560527
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Control engineering
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| Research Institution | Kyoto University |
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Principal Investigator |
FURUTANI EIKO 京都大学, 工学(系)研究科(研究院), 准教授 (40219118)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 麻酔制御 / 時変モデル / propofol / remifentanil / aepEX / 鎮痛度 / 鎮痛侵害受容指数 |
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| Research Abstract |
In this research, we have studied an anesthesia control system considering time variability of kinetics and effect of anesthetic drugs during surgery. First, we developed a pharmacokinetic model with a time-varying clearance, which represents time variability of hypnotic effect of propofol, an anesthetic drug. Utilizing the model, hypnosis can be kept properly by maintaining estimated effect-site concentration of propofol at a constant level. Second, we confirmed that Analgesia/Nociception Index is more effective as an analgesia index than existing indices, and constructed a hypnosis and analgesia control method considering interaction of propofol and remifentanil, an analgesic drug. Simulation results show that the developed control method can maintain hypnosis and analgesia appropriately if sufficient analgesia is achieved at the beginning of surgery.
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