2013 Fiscal Year Final Research Report
Development of biologic scaffold materials composed of extracellular matrix by means of the supercritical fluid technology with ultrasonic irradiation.
| Project/Area Number |
23560913
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Properties in chemical engineering process/Transfer operation/Unit operation
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHIMURA Hideo 福岡大学, 医学部, 教授 (80178996)
IRIE Keiichi 福岡大学, 加齢脳科学研究所, ポストドクター (50509669)
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| Project Period (FY) |
2011 – 2013
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| Keywords | バイオスカフォールド / 二酸化炭素 / 再生医療 / 超臨界流体 / 超音波 |
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| Research Abstract |
We attempted to generate biologic scaffold materials composed of extracellular matrix (ECM) from animal tissues or organs by means of the supercritical fluid technology. In order to obtain the biologic scaffold materials which may overcome a severe shortage of donor organs for organ transplant, the separation of cellular components leading to allograft rejection and decellularization of whole organs, such as kidneys livers, hearts of rats and pigs was achieved by ultrasonic irradiation in liquid carbon dioxide at high pressure condition. The structural data of decellularized organs were obtained by a micro-focus X-ray CT. These structural data of decellularized organs may lead to multi production of biologic scaffold materials composed of extracellular matrix for donor organs for organ transplant in an industrial scale.
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[Journal Article] Differences in TLR9-dependent inhibitory effects of H(2)O(2)-induced IL-8 secretion and NF-kappa B/I kappa B-alpha system activation by genomic DNA from five Lactobacillus species2013
Author(s)
Hiramatsu Y, Satho T, Irie K, Shiimura S, Okuno T, Sharmin T, Uyeda S, Fukumitsu Y, Nakashima Y, Miake F, Kashige N
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Journal Title
Microbes and Infection
Volume: 15(2)
Pages: 96-104
Peer Reviewed
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[Journal Article] ADAMTS13 gene deletion enhances plasma high-mobility group box1 elevation and neuroinflammation in brain ischemia-reperfusion injury2012
Author(s)
Fujioka M, Nakano T, Hayakawa K, Irie K, Akitake Y, Sakamoto Y, Mishima K, Muroi C, Yonekawa Y, Banno F, Kokame K, Miyata T, Nishio K, Okuchi K, Iwasaki K, Fujiwara M, Siesjö BK
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Journal Title
Neurological Sciences
Volume: 33(5)
Pages: 1107-1115
Peer Reviewed
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[Journal Article] Measuement of cerebral blood oxygenation during a verbal memory task by means of fNIRS2011
Author(s)
Kenji Mishima, Kiyoshi Matsuyama, Takafumi Kato, Tadashi Suetsugu, Shigeto Aramaki, Hiroaki Tanaka, Yasuki Higaki, Soichi Ando, Keiichi Irie, Sei Higuchi, Yoshiharu Akitake, Kenichi Mishima, Michihiro Fujiwara
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Journal Title
IEEE Region 10 Conference (TENCON) 2011
Volume: 10 Conference (TENCON) 2011 1
Pages: 1-2
Peer Reviewed
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[Journal Article] Effect of rock-paper-scissors exercise on cerebral blood oxygenation during a verbal memory task measured by fNIRS2011
Author(s)
Kenji Mishima, Kiyoshi Matsuyama, Takafumi Kato, Tadashi Suetsugu, Shigeto Aramaki, Hiroaki Tanaka, Yasuki Higaki, Soichi Ando, Keiichi Irie, Sei Higuchi, Yoshiharu Akitake, Kenichi Mishima, Michihiro Fujiwara
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Journal Title
2011 IEEE TENCON International Conference on Signal Processing
Volume: 1
Pages: 1-2
Peer Reviewed
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[Presentation] 肪嗜好性に対する高脂肪食摂食期間が及ぼすカンナビノイドシステムの変化2013
Author(s)
山下郁太, 山口竜司, 樋口聖, 中野貴文, 林稔展, 松尾宏一, 入江圭一, 佐藤朝光, 松山清, 三島健司, 桂林秀太郎, 高崎浩太郎, 窪田香織, 三島健一, 岩崎克典, 藤原道弘
Organizer
第66回日本薬理学会西南部会
Place of Presentation
福岡
Year and Date
2013-11-16
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[Presentation] Preparation of Extracellular Matrix from Animal Tissue by Ultrasonic Irradiation in Liquid CO22012
Author(s)
K. Mishima, H. Yokota, T. Kato, T. Suetsugu, X. Wei, K. Irie, K. Mishim, M. Fujiwara, H. Shimura, K. Matsuo, K. Matsuyama, T. Harada
Organizer
MTMS'12
Place of Presentation
広島
Year and Date
20120925-27
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[Presentation] Formation of Microcompositesα-Lipoic Acid and Hydrogenated Colza Oil by PGSS2012
Author(s)
K. Mishima, M. Honjo, H. Yokota, T. Kato , T. Suetsugu, X. Wei, K. Irie, K. Mishim, M. Fujiwara, T. Kakuda, K. Matsuyama, T. Harada
Organizer
MTMS'12
Place of Presentation
広島
Year and Date
20120925-27
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