2013 Fiscal Year Final Research Report
Molecular sensing using model membranes
| Project/Area Number |
23560940
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biofunction/Bioprocess
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| Research Institution | Japan Advanced Institute of Science and Technology |
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Principal Investigator |
VESTERGAARD Catherine 北陸先端科学技術大学院大学, 大学院教育イニシアティブセンター, 准教授 (20582943)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 免疫センサー / 流動性 / 毒性 / 神経保護 / アミロイド-β / アルツハイマー病 / 電気化学 / 生体模倣センサー |
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| Research Abstract |
We have (i) shown that amyloid beta (Ab) interacts with membranes in a species-dependent and membrane composition manner. They cause membrane transformation, breach and viscosity. These may contribute towards understanding toxicity mechanisms; (ii) studied how oxidation of cholesterol influences membrane dynamics, demonstrating that temperature increase renders oxidized membranes more fluid. We have similar findings using biological cells. The findings are useful for clarifying the impact of cholesterol in Ab-induced toxicity; (iv) oxidized membranes enhance Ab's association with membranes; (v) potential neuro-protective agents interact with membranes in a structure-dependent manner as does their ability to inhibit Ab aggregation. Unraveling the importance of these compounds, at a functional group level opens the key to tailored design of potential bioactive drug candidates. We have developed an immunosensor chip for Ab.
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Research Products
(22 results)
