The molecular and neuronal mechanisms for the germline-mediated regulation of the chemotactic behavior

2013 Fiscal Year Final Research Report

• Project/Area Number: 23570007
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Genetics/Genome dynamics
• Research Institution: Kyushu University
• Principal Investigator: FUJIWARA Manabi 九州大学, 理学(系)研究科(研究院), 助教 (70359933)
• Project Period (FY): 2011 – 2013
• Keywords: 行動遺伝

Research Abstract

The molecular and neuronal mechanisms for the germline-mediated regulation of the chemotactic behaviorAnimals adequately change their behavioral patterns according to their developmental stage. We found that C. elegans larvae show a different preference in odorant from the adult. We also found that the germline loss makes adult animals show the larva-like odorant preference. These results implicate that some signals may be released from germline cells, which proliferate through the larval stages and the adult. By mutant analyses and a genome-wide RNAi screening, the energy state of the animal during larval stages is shown to be important for the germline-mediated regulation of chemotaxis.

Research Products

• [Journal Article] Forgetting in C. elegans is accelerated by neuronal communication via the TIR-1/JNK-1 pathway (2013)
  • Author(s): Inoue A, Sawatari E, Hisamoto N, Kitazono T, Teramoto T, Fujiwara M, Matsumoto K, and Ishihara T.
  • Journal Title: Cell Rep. Volume: 28;3(3) Pages: 808-19
  • DOI: 10.1016/j.celrep.2013.02.019
  • Peer Reviewed
• [Journal Article] Behavioral choice between conflicting alternatives Is regulated by a receptor guanylyl cyclase, GCY-28, and a Receptor Tyrosine Kinase, SCD-2, in AIA Interneurons of Caenorhabditis elegans (2011)
  • Author(s): Shinkai Y, Yamamoto Y, Fujiwara M, Tabata T, Murayama T, Hirotsu T, Ikeda DD, Tsunozaki M, Iino Y, Bargmann CI, Katsura I, Ishihara T.
  • Journal Title: Journal of Neuroscience Volume: 31 Pages: 3007-15
  • DOI: 10.1523/JNEUROSCI.4691-10.2011
  • Peer Reviewed
• [Journal Article] An expanded palette of genetically encoded Ca2+ indicators (2011)
  • Author(s): Zhao Y, Araki S, Wu J, Teramoto T, Chang YF, Nakano M, Abdelfattah AS, Fujiwara M, Ishihara T, Nagai T, Campbell RE.
  • Journal Title: Science Volume: 333 Pages: 1888-91
  • DOI: 10.1126/science.1208592
  • Peer Reviewed
• [Presentation] 線虫の感覚行動のライフサイクルにおける変化 (2013)
  • Author(s): 藤原学
  • Organizer: 第36回日本分子生物学会
  • Place of Presentation: 神戸
  • Year and Date: 20131203-06
• [Presentation] 線虫の成長に伴う行動変化に関わるミトコンドリアの働き (2012)
  • Author(s): 藤原学
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡
  • Year and Date: 20121211-14
• [Presentation] 生殖細胞が制御する線虫の感覚行動日本遺伝学会 (2012)
  • Author(s): 藤原学
  • Organizer: 84回大会
  • Place of Presentation: 九州大学
  • Year and Date: 20120924-26
• [Presentation] Chemotaxis behavior is regulated by germline in C. elegans (2012)
  • Author(s): M. Fujiwara
  • Organizer: 2012 EMBO conference series : C. elegans Neurobiology
  • Place of Presentation: Heidelberg
  • Year and Date: 20120614-17
• [Presentation] Chemotaxis behavior is regulated by germline in C. elegans (2011)
  • Author(s): M. Fujiwara
  • Organizer: 18^<th> International C. elegans meeting University of California
  • Place of Presentation: Los Angeles
  • Year and Date: 20110622-26
• [Remarks]
  • URL: http://www.biology.kyushu-u.ac.jp/~bunsiide/