2013 Fiscal Year Final Research Report
Morphological analysis of synapse underlying pheromonal memory
| Project/Area Number |
23570084
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphology/Structure
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| Research Institution | Tokyo Metropolitan Institute of Medical Science |
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Principal Investigator |
ICHIKAWA Masumi 公益財団法人東京都医学総合研究所, 基盤技術研究センター, 副参事研究員 (20124414)
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| Co-Investigator(Renkei-kenkyūsha) |
MORIYA Keiko 公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 研究員 (70392371)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 副嗅球 / ニューロン / 鋤鼻系 / 電子顕微鏡 / シナプス可塑性 / フェロモン / マウス |
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| Research Abstract |
Pregnancy in female mice is maintained by formation of pheromonal memory of partner male. The reciprocal synapse in the accessory olfactory bulb has been shown to play important role in this memory formation. The morphological change of this synapse is examined electron microscopically using transgenic mice in which the neuron is marked activity-dependently by GFP expression.
The size of synapse in these female mice was examined after mating. The size in GFP positive neuron was larger than those in GFP negative neuron. This result indicates that the morphological change of synapse take place in association with memory formation of pheromone. This study is expected to useful not only for research in olfaction but also for those generally in learning and memory.
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