2013 Fiscal Year Final Research Report
The roles of immediate early genes and the morphological changes of dendritic spines in the filial imprinting of precocial birds.
| Project/Area Number |
23570098
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Animal physiology/Animal behavior
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| Research Institution | Teikyo University |
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Principal Investigator |
HOMMA Koichi 帝京大学, 薬学部, 教授 (90251438)
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| Co-Investigator(Renkei-kenkyūsha) |
AOKI Naoya 帝京大学, 薬学部, 助教 (50525334)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 学習臨界期（感受性期） / 刷り込み（刻印付け） / 甲状腺ホルモン / メモリープライミング / 早期学習 / BDNF / 最初期遺伝子 / ヨードチロニン脱ヨウ素酵素タイプ2 |
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| Research Abstract |
In some cases, learning that occurs during the sensitive or critical period lays the foundation for future learning. Filial imprinting in precocial birds is the process of forming a social attachment during a sensitive period, restricted to the first few days after hatching. We showed that the thyroid hormone(T3) determines the start of the sensitive period. Imprinting training in chicks causes rapid inflow of T3 in brain vascular endothelial cells. The T3 thus initiated and extended the sensitive period to last more than 1 week and primed subsequent learning.The mechanisms included the activation of the immediate early genes and the morphological changes of dendritic spines in brain. The timing and duration of the sensitive period for learning has been believed to be developmentally fixed.However, there is now reason to believe thatlearning itself starts the sensitive period, and once "memory priming" occurs, the sensitive period does not close but remains open.
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[Journal Article] Potential role of voltage-sensing phosphatases in regulation of cell structure through the production of PI (3, 4)P22014
Author(s)
Yamaguchi, S., Kurokawa, T., Taira, I., Aoki, N., Sakata, S., Okamura, Y. and Homma, K.J.
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Journal Title
J. Cell Physiol.
Volume: 229(4)(PubMed PMID : 24038012)
Pages: 422-433
DOI
Peer Reviewed
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[Journal Article] Thyroid hormone determines the start of the sensitive period of imprinting and primes later learning2012
Author(s)
Yamaguchi, S., Aoki, N., Kitajima, T., Iikubo, E., Katagiri, S., Matsushima, T. and Homma, K.J.
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Journal Title
Nat. Commun.
Volume: 3(PubMed PMID : 23011135; PubMed Central PMCID : PMC3658000)
Pages: 1081
DOI
Peer Reviewed
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[Journal Article] 3' Phosphatase activity toward phosphatidylinositol 3, 4-bisphosphate [PI (3, 4) P2] by voltage-sensing phosphatase (VSP)2012
Author(s)
Kurokawa, T., Takasuga, S., Sakata, S., Yamaguchi, S., Horie, S., Homma, K.J., Sasaki, T. and Okamura, Y.
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Journal Title
Proc. Natl. Acad. Sci. U.S.A.
Volume: 19: 109(25)(Epub : 2012 May 29. PubMed PMID : 22645351; PubMed Central PMCID : PMC3382541)
Pages: 10089-10094
DOI
Peer Reviewed
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[Journal Article] Activation of brain-derived neurotrophic factor/tropomyosin-related kinase B signaling accompanying filial imprinting in domestic chicks (Gallus gallus domesticus)2011
Author(s)
Yamaguchi, S., Aoki, N., Kobayashi, D., Kitajima, T., Iikubo, E., Katagiri, S., Matsushima, T. and Homma, K.J.
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Journal Title
Neuroreport
Volume: 22(17)(PubMed PMID : 22015740)
Pages: 929-934
DOI
Peer Reviewed
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[Journal Article] Molecular function of microtubule-associated protein 2 for filial imprinting in domestic chicks (Gallus gallus domesticus)2011
Author(s)
Yamaguchi, S., Katagiri, S., Aoki, N., Iikubo, E., Kitajima, T., Matsushima, T. and Homma, K.J.
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Journal Title
Neurosci. Res.
Volume: 69(1)(Epub 2010 Sep 19. PubMed PMID : 20858519)
Pages: 32-40
DOI
Peer Reviewed
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[Presentation] Brain-derived neurotrophic factor (BDNP)/TrkB signaling is activated through filial imprinting in domestic chicks (Gallus gallus domesticus)2011
Author(s)
Aoki, N., Yamaguchi, S., Kobayashi, D., Kitajima, T., Iikubo, E., Katagiri, S., Matsushima, T. and Homma, K.J.
Organizer
国際比較生理生化学会議(ICCPB2011 )
Place of Presentation
名古屋国際会議場
Year and Date
2011-06-02
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