2013 Fiscal Year Final Research Report
Causes of fragile testes revealed by evolutionary studies of gene expression regulation
| Project/Area Number |
23570123
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biodiversity/Systematics
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| Research Institution | Kyoto Institute of Technology (2012-2013)
National Institute of Genetics (2011) |
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Principal Investigator |
TAKANO Toshiyuki 京都工芸繊維大学, ショウジョウバエ遺伝資源センター, 教授 (90202150)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 種分化 / 分子共進化 / ショウジョウバエ / 遺伝子発現 / シス調節因子 / トランス制御因子 |
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| Research Abstract |
Spermatogenesis defects are frequently observed in interspecific hybrids of Drosophila. Indeed, hybrid male sterility evolves much faster than female sterility. To understand how the hybrid sterility can arise so quickly, we characterized the expression profile of testes of Drosophila melanogaster and found that transcribed and translated genes tended significantly to cluster. More importantly, genes exhibiting strain-specific higher or lower expression also tended to cluster. It is conceivable that testis transcription is not strictly controlled and therefore that the testis possesses many noisy transcripts. On the other hand, by using interspecific hybrids, we obtained evidence that hybrid incompatibilities between cis- and trans-regulatory elements are accumulating much faster than generally considered. Taken together, we proposed that regulatory incompatibilities contribute to the fast evolution of hybrid male sterility.
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[Journal Article] Allelic asymmetry of the Lethal hybrid rescue (Lhr) gene expression in the hybrid between Drosophila melanogaster and D. simulans : confirmation by using genetic variations of D. melanogaster2014
Author(s)
Shirata, M., Araye, Q., Maehara, K., Enya, S., Takano-Shimizu, T., and Sawamura, K.
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Journal Title
Genetica
Volume: 142
Pages: 43-48
DOI
Peer Reviewed
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[Journal Article] Starvation-induced elevation of taste responsiveness and expression of a sugar taste receptor gene in Drosophila melanogaster2012
Author(s)
Nishimura, A., Ishida, Y., Takahashi, A., Okamoto, H., Sakabe, M., Itoh, M., Takano-Shimizu, T., and Ozaki, M.
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Journal Title
Journal of Neurogenetics
Volume: 26
Pages: 206-215
DOI
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[Journal Article] Cuticular hydrocarbon content that affects male mate preference of Drosophila melanogaster from West Africa2012
Author(s)
Takahashi, A., Fujiwara-Tsujii, N., Yamaoka, R., Itoh, M., Ozaki, M., and Takano-Shimizu, T.
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Journal Title
International Journal of Evolutionary Biology Volume 2012
Volume: (Article ID) 278903
DOI
Peer Reviewed
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