2013 Fiscal Year Final Research Report
structural studies of the mechanism of eukaryotic translation initiation
| Project/Area Number |
23570143
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Structural biochemistry
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| Research Institution | Shimane University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | タンパク質 / 立体構造解析 / 翻訳開始 |
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| Research Abstract |
The translation initiation complex is important for a fundamental biological process and it also attracts attention as a target for a new class of antibiotics and drug development. In this study, it has been focused on the molecular mechanism of the signal transduction how translation is really started in the recognition of the translation initiation codon on mRNA by ribosome. In this research period, the structure of eIF1 was determined and the interaction region of eIF1 with eIF2, eIF3c and eIF5 were identified. In addition, based on the results from yeast genetic and biochemical studies, we could explain in detail the molecular mechanism of the translation initiation process with ribosome and initiation factors.
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