Grant-in-Aid for Scientific Research (C)
In the vertebrate brain, nerve cells are managing memory and learning. The nerve cells are connected via synapses, which are real nature of the memory and learning. NMDA receptor and related proteins at the synapse are essential for the regulation of synaptic strength. The proteins form quite large complex and they communicate each other via interaction or chemical modification. Using structural biology technics, we try to understand how they communicate, how they form complexes, and how they work for the synaptic strength regulation. Rap1 molecule is a GTPase, a kind of molecular switch belongs to Ras super family. This molecule works as a signal transduction factor in a nerve cell and related with the NMDA receptor protein complex. We succeeded solving high-resolution crystal structure of the Rap1 molecule, GTP analogue bound form and GDP bound form.
J. Gen. Virol.
Journal of Biological Chemistry
FEMS Microbiol. Lett.
Nucleic Acids Res
Attribution of KAKENHI