2013 Fiscal Year Final Research Report
The structure and function of new drug excreting transporter MATE in mannmal
| Project/Area Number |
23570168
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Setsunan University (2012-2013)
Okayama University (2011) |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 生化学 / 薬物排出 / 輸送体 / 有機カチオン / 薬物副作用軽減 |
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| Research Abstract |
There are so many transporters in kidney and these transporters are concerned about transepithelial transport. These transporters don't work alone but may be working together. From this idea, drug excretion is precisely controlled and these should be well organized mechanism. MATE transporter is also controlled with these mechanism. In MATE transporter, there is long tail in C-terminus region, so, in this region should hove some function for regulation. From this hypothesis, several functional proteins are identified.
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Research Products
(15 results)
