2013 Fiscal Year Final Research Report
Analysis of structural and functional changes in immunoglobulins during the maturation of the immune response
| Project/Area Number |
23570169
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Kochi University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 免疫学 / 抗体 / 免疫応答成熟 / 抗原親和性 / 免疫記憶 / 体細胞突然変異 |
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| Research Abstract |
By analyzing sequences of the IgM genes expressed in plasma cells which were isolated from secondary immunized mice, we found many VH genes which were rarely found in IgM repertoire of the primary immune response or in IgG repertoire. These IgM antibodies showed very low affinity to antigen, although they activated complement pathway and signaling pathway when they recognized antigens. These findings indicated that in the secondary immune response to T cell-dependent antigen, not only high affinity IgG antibodies but also low affinity IgM antibodies are produced.
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[Journal Article] In vivo role of aldehyde reductase2012
Author(s)
Motoko Takahashi, Satoshi Miyata, Junichi Fujii, Yoko Inai, Shigemitsu Ueyama, Motoko Araki, Tomoyoshi Soga, Reiko Fujinawa, Chiaki Nishitani, Shigeru Ariki, Takeyuki Shimizu, Tomomi Abe, Yoshito Ihara, Morimitsu Nishikimi, Yasunori Kozutsumi, Naoyuki Taniguchi, and Yoshio Kuroki
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Journal Title
Biochim. Biophys. Acta.
Volume: 1820
Pages: 1787-1796
DOI
Peer Reviewed
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Author(s)
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Journal Title
J. Immunol.
Volume: 187
Pages: 2586-2594
DOI
Peer Reviewed
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