2013 Fiscal Year Final Research Report
Analyses of the intracellular redox regulation in Saccharomyces cerevisiae
| Project/Area Number |
23570180
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | National Agriculture and Food Research Organization |
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Principal Investigator |
NAKAMURA Toshihide 独立行政法人農業・食品産業技術総合研究機構, 食品総合研究所・応用微生物研究領域, 主任研究員 (60391588)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 酸化ストレス / 遺伝子発現 / Eos1 |
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| Research Abstract |
EOS1, whose function is important for oxidative stress tolerance in budding yeasts, was subjected to functional analyses. Based on phenotypic analyses using the partial deletion mutants of EOS1, I found the important region for enzymatic activity in Eos1 protein. As the results of gene expression analyses in EOS1 deletion variant, expression levels of many genes involved in elimination of reactive oxygen species (ROS) were increased. However, the expression levels of ROS degrading enzymes localized in intracellular organelles were reduced.
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Research Products
(5 results)
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[Journal Article] Identification of an acetate-tolerant strain of Saccharomyces cerevisiae and characterization by gene expression analysis2012
Author(s)
Haitani, Y., Tanaka, K., Yamamoto, M., Nakamura, T., Ando, A., Ogawa, J. and Shima, J.
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Journal Title
Journal of Bioscience and Bioengineering
Volume: 114(6)
Pages: 648-651
DOI
Peer Reviewed
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