2013 Fiscal Year Final Research Report
Study of autonomous oscillation in PEG-crosslinked actin hydrogel
Project/Area Number |
23570181
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Functional biochemistry
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Research Institution | Nippon Institute of Technology |
Principal Investigator |
SANO Ken-Ichi 日本工業大学, 工学部, 准教授 (80321769)
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Project Period (FY) |
2011 – 2013
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Keywords | アクチン / ダイナミックインスタビリティ / ナノバイオ |
Research Abstract |
We succeeded in synthesizing chemically poly-ethylene glycol cross-linked hydrogels comprised of actin. We have found that the storage modulus of this actin hydrogel autonomously oscillated for more than ten hours. The oscillatory properties of the actin hydrogels were based on both the treadmilling and gelation by chemical crosslinking of the filamentous actin structures. Thus oscillation can be caused by dynamic instability of actin filament. In this study, I developed simultaneous measurement system both mechanical strength and polymerization of actin, and build a model of oscillating actin gel based on dynamic instability. Additionally, exploring the specific motility of the cytoskeletal protein hydrogel when combined with kinesin linear motor protein.
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[Presentation] Slime mold in conflicting2013
Author(s)
Sano K., Ichimura M., Arai Y., Nakayama N., Hara M., Aono M.
Organizer
International Symposium on Advanced Soft Materials
Place of Presentation
札幌市
Year and Date
2013-10-18
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