2013 Fiscal Year Final Research Report
Regulation of heme oxygenase 1 gene expression by heat shock factor1
| Project/Area Number |
23570216
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Molecular biology
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| Research Institution | Yasuda Women's University |
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Principal Investigator |
INOUE Sachie 安田女子大学, 薬学部, 教授 (60159978)
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| Co-Investigator(Kenkyū-buntansha) |
AKAGI Reiko 安田女子大学, 薬学部, 教授 (50150967)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 熱ショック因子 / ストレス応答 / ヘムオキシゲナーゼ / 発現制御 / 生体防御 / 小Maf転写因子 |
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| Research Abstract |
Heme-degrading enzyme, heme oxygenase-1 (HO-1), plays a role protecting cells against to oxidative stress. The HO-1 is also known as heat shock protein 32 (Hsp32), however, the heat inducible HO-1 is different in species, cell lines, and culture conditions. In this study, we examined the role of heat shock factor 1 (HSF1) on the regulation of HO-1 expression by using wild-type and HSF1-null mouse embryonic fibroblast (MEF). Our results showed that HSF1 suppressed heme-induced HO-1 expression in normal growth condition and facilitated heme-induced HO-1 expression during heat shock. In conclusion, HSF1 protect cells by not only inducing the expression of Hsps under heat stress condition but also fine controlling the expression of HO-1 under various stress conditions.
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[Journal Article] Heat shock factor 2 is required for maintaining proteostasis against febrile-range thermal stress and polyglutamine2011
Author(s)
Shinkawa T, Tan K, Fujimoto M, Hayashida N, Yamamoto K, Takaki E, Takii R, Prakasam R, Inouye S, Mezger V, Nakai A.
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Journal Title
Mol Biol Cell
Volume: 22(19)
Pages: 3571-83
DOI
Peer Reviewed
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