2013 Fiscal Year Final Research Report
Analysis of storage mRNP components
| Project/Area Number |
23570218
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Molecular biology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
MATSUMOTO Ken 独立行政法人理化学研究所, 吉田化学遺伝学研究室, 専任研究員 (60222311)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 翻訳 |
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| Research Abstract |
To elucidate regulatory mechanisms involved in translation and stability of mRNA, it is essential to understand functions of mRNP components. In this work, we further characterized mRNP components RAP55/Lsm14 and P100 that we previously identified. To obtain proteins that functionally interact with RAP55, we performed a screening based on the co-localization with RAP55, effects of the overexpression on the formation of mRNP granules or the disappearance of RAP55 from mRNP granules. In addition, to understand the mechanism with which P100 disappears from oocytes during oocyte maturation, we prepared several point mutants and analyzed their stability.
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Research Products
(22 results)
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[Journal Article] PRMT1 is required for RAP55 to localize to processing bodies2012
Author(s)
Matsumoto, K., Nakayama, H., Yoshimura, M., Masuda, A., Dohmae, N., Matsumoto, S., and Tsujimoto, M.
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Journal Title
RNA Biol.
Volume: 9
Pages: 610-623
DOI
Peer Reviewed
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[Journal Article] The NS1 protein of influenza A virus interacts with cellular processing bodies (P-bodies) and stress granules through RNA-associated protein 55 (RAP55) during virus infection2012
Author(s)
Mok, B. W.-Y., Song, W., Wang, P., Tai, H., Chen, Y.-X., Zheng, M., Wen, X., Lau, S.-Y., Wu, W. L., Matsumoto, K., Yuen, K.-Y., and Chen, H.
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Journal Title
J. Virol.
Volume: 86
Pages: 12695-12707
DOI
Peer Reviewed
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[Presentation] Y-box binding protein-1 as a molecular target for potentiating chemotherapeutic drugs2012
Author(s)
Yu, Y.-N., Inoue, I., Guo, T., Ng, C.-T., Wong, J.-Y., Matsumoto, K., Yip, G. W., and Bay, B.-H.
Organizer
The 24^<th> EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
Place of Presentation
Dublin, Ireland
Year and Date
2012-11-09
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[Presentation] TNRC6 proteins interact with multiple Argonautes to form large RNP aggregates2011
Author(s)
Takimoto, K., Matsumoto, K., Yamashita, S., Muramatsu, R., Yokoyama, S., and Wakiyama, M.
Organizer
RNA 2011: 16th Annual Meeting of the RNA Society in conjunction with 13th Annual Meeting of the RNA Society of Japan
Place of Presentation
Kyoto
Year and Date
2011-06-15
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