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2013 Fiscal Year Final Research Report

Analysis of storage mRNP components

Research Project

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Project/Area Number 23570218
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Molecular biology
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

MATSUMOTO Ken  独立行政法人理化学研究所, 吉田化学遺伝学研究室, 専任研究員 (60222311)

Project Period (FY) 2011 – 2013
Keywords翻訳
Research Abstract

To elucidate regulatory mechanisms involved in translation and stability of mRNA, it is essential to understand functions of mRNP components. In this work, we further characterized mRNP components RAP55/Lsm14 and P100 that we previously identified. To obtain proteins that functionally interact with RAP55, we performed a screening based on the co-localization with RAP55, effects of the overexpression on the formation of mRNP granules or the disappearance of RAP55 from mRNP granules. In addition, to understand the mechanism with which P100 disappears from oocytes during oocyte maturation, we prepared several point mutants and analyzed their stability.

  • Research Products

    (22 results)

All 2014 2013 2012 2011 Other

All Journal Article (9 results) (of which Peer Reviewed: 8 results) Presentation (12 results) Remarks (1 results)

  • [Journal Article] FETタンパク質ファミリーの疾患との関わり2014

    • Author(s)
      松本健
    • Journal Title

      生化学

      Volume: 86 Pages: 274-280

  • [Journal Article] EWS represses cofilin 1 expression by inducing nuclear retention of cofilin 1 mRNA2013

    • Author(s)
      Huang, L., Kuwahara, I., and Matsumoto, K.
    • Journal Title

      Oncogene, advance online publication

    • DOI

      10.1038/onc.2013.255

    • Peer Reviewed
  • [Journal Article] Silencing the YB-1 gene inhibits cell migration in gastric cancer in vitro2013

    • Author(s)
      Guo, T. T., Yu, Y.-N., Yip, G. W.-C., Matsumoto, K., and Bay, B.-H.
    • Journal Title

      Anat. Rec.

      Volume: 296 Pages: 891-898

    • DOI

      10.1002/ar.22702

    • Peer Reviewed
  • [Journal Article] PRMT1 is required for RAP55 to localize to processing bodies2012

    • Author(s)
      Matsumoto, K., Nakayama, H., Yoshimura, M., Masuda, A., Dohmae, N., Matsumoto, S., and Tsujimoto, M.
    • Journal Title

      RNA Biol.

      Volume: 9 Pages: 610-623

    • DOI

      10.4161/rna.19527

    • Peer Reviewed
  • [Journal Article] アフリカツメガエル卵母細胞内の翻訳抑制因子P100に結合する母性mRNAの探索2012

    • Author(s)
      中村依子, 中井雄治, 松本健
    • Journal Title

      日大口腔科学

      Volume: 38 Pages: 33-36

    • Peer Reviewed
  • [Journal Article] Surmounting chemoresistance by targeting the Y-Box Binding Protein-12012

    • Author(s)
      Inoue, I., Matsumoto, K., Yu, Y., and Bay, B.-H.
    • Journal Title

      Anat. Rec.

      Volume: 295 Pages: 215-222

    • DOI

      10.1002/ar.22401

    • Peer Reviewed
  • [Journal Article] PRAS40 is a functionally critical target for EWS repression in Ewing's sarcoma2012

    • Author(s)
      Huang, L., Nakai, Y., Kuwahara, I., and Matsumoto, K.
    • Journal Title

      Cancer Res.

      Volume: 72 Pages: 1260-1269

    • DOI

      10.1158/0008-5472.CAN-11-2254

    • Peer Reviewed
  • [Journal Article] YB-1, Y-box binding protein-1, is a porter to lead influenza virus ribonucleoprotein complexes to microtubules2012

    • Author(s)
      Kawaguchi, A., Matsumoto, K., and Nagata, K.
    • Journal Title

      J. Virol.

      Volume: 86 Pages: 11086-11095

    • DOI

      10.1128/JVI.00453-12

    • Peer Reviewed
  • [Journal Article] The NS1 protein of influenza A virus interacts with cellular processing bodies (P-bodies) and stress granules through RNA-associated protein 55 (RAP55) during virus infection2012

    • Author(s)
      Mok, B. W.-Y., Song, W., Wang, P., Tai, H., Chen, Y.-X., Zheng, M., Wen, X., Lau, S.-Y., Wu, W. L., Matsumoto, K., Yuen, K.-Y., and Chen, H.
    • Journal Title

      J. Virol.

      Volume: 86 Pages: 12695-12707

    • DOI

      10.1128/JVI.00647-12

    • Peer Reviewed
  • [Presentation] YBAP1によるYB-1の活性調節2014

    • Author(s)
      松本健, 吉村麻美
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Year and Date
      2014-03-28
  • [Presentation] RNA結合蛋白質EWSによるmRNAの転写後調節2013

    • Author(s)
      黄琳, 中井雄治, 桑原いく, 松本健
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Year and Date
      2013-03-29
  • [Presentation] EWS represses protein expression by inducing nuclear retention of its mRNA targets. The 2^<nd> Meeting of RNA and Biofunctions-Asia Study2013

    • Author(s)
      Huang, L., and Matsumoto, K.
    • Organizer
      RNA Biofunctions and Viruses
    • Place of Presentation
      Hakata, Fukuoka
    • Year and Date
      2013-01-10
  • [Presentation] EWS induces the nuclear retention of its target mRNAs and represses their protein expression in Ewing's sarcoma2012

    • Author(s)
      Huang, L., Kuwahara, I., and Matsumoto, K.
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-14
  • [Presentation] Y-box binding protein-1 as a molecular target for potentiating chemotherapeutic drugs2012

    • Author(s)
      Yu, Y.-N., Inoue, I., Guo, T., Ng, C.-T., Wong, J.-Y., Matsumoto, K., Yip, G. W., and Bay, B.-H.
    • Organizer
      The 24^<th> EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
    • Place of Presentation
      Dublin, Ireland
    • Year and Date
      2012-11-09
  • [Presentation] ツメガエルの卵成熟に関与するmRNP構成因子P100には何が結合するのか2012

    • Author(s)
      中村依子, 中井雄治, 松本健, 城座映明
    • Organizer
      XCIJ-All/MA研究集会
    • Place of Presentation
      東京
    • Year and Date
      2012-07-14
  • [Presentation] アフリカツメガエル卵母細胞特異的蛋白質P100に結合する卵成熟関与遺伝子2012

    • Author(s)
      中村依子, 中井雄治, 松本健, 城座映明
    • Organizer
      平成24年度日本生化学会関東支部例会
    • Place of Presentation
      前橋
    • Year and Date
      2012-06-23
  • [Presentation] RAP55 is important for the assembly, size and composition of cytoplasmic mRNP granules2012

    • Author(s)
      Matsumoto, K., Minami, M., Minami, Y., Matsumoto, S.
    • Organizer
      The 10^<th> Asia Pacific Microscopy Conference
    • Place of Presentation
      Perth, Australia
    • Year and Date
      2012-02-07
  • [Presentation] Functional repression of an EWS-bound mRNA in Ewing's sarcoma2011

    • Author(s)
      Huang, L., Nakai, Y., Kuwahara, I., and Matsumoto, K.
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-14
  • [Presentation] Identification of EWS-bound mRNAs and their functional role in Ewing's sarcoma cells2011

    • Author(s)
      Huang, L., Nakai, Y., Kuwahara, I., and Matsumoto, K.
    • Organizer
      NTU-JST Joint Meeting on RNA and Biofunctions-Asia Studies
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2011-11-11
  • [Presentation] TNRC6 proteins interact with multiple Argonautes to form large RNP aggregates2011

    • Author(s)
      Takimoto, K., Matsumoto, K., Yamashita, S., Muramatsu, R., Yokoyama, S., and Wakiyama, M.
    • Organizer
      RNA 2011: 16th Annual Meeting of the RNA Society in conjunction with 13th Annual Meeting of the RNA Society of Japan
    • Place of Presentation
      Kyoto
    • Year and Date
      2011-06-15
  • [Presentation] Regulation of the activities of YB-1 by YBAP12011

    • Author(s)
      Matsumoto, K., and Yoshimura, M.
    • Organizer
      RNA 2011: 16th Annual Meeting of the RNA Society in conjunction with 13th Annual Meeting of the RNA Society of Japan
    • Place of Presentation
      Kyoto
    • Year and Date
      2011-06-15
  • [Remarks]

    • URL

      http://www.riken.jp/matsumok/index.html

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Published: 2015-07-16  

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