2013 Fiscal Year Final Research Report
Functional analysis of proteasome activators
| Project/Area Number |
23570221
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
CHIBA Tomoki 筑波大学, 生命環境系, 教授 (00311423)
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| Project Period (FY) |
2011 – 2013
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| Keywords | タンパク質分解 / 翻訳後修飾 / ストレス応答 / 遺伝子改変動物 |
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| Research Abstract |
Intracellular protein degradation is highly regulated by the Ubiquitin and Proteasome system (UPS), which plays critical roles in many biological processes such as cell cycle progression, stress response, signal transduction, and so on. The impairment of the UPS is associated with diverse array of diseases such as neurodegenerative diseases, and immune diseases.
Proteasome is a barrel-shaped multisubunit protease complex that consists of latent 20S core particle (CP) and regulatory particles (RPs). The function of CP is regulated by evolutionarily conserved multiple RPs in the cells. However the function and physiological roles of each RPs are not well understood. To reveal the specific function of each RPs, we generated knockout mice of one of the proteasome-associated protein whose function has not yet been elucidated in mammal.
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[Journal Article] Acetylation-Mediated Proteasomal Degradation of Core Histones during DNA Repair and Spermatogenesis2013
Author(s)
Qian MX, Pang Y, Liu CH, Haratake K, Du BY, Ji DY, Wang GF, Zhu QQ, Song W, Yu Y, Zhang XX, Huang HT, Miao S, Chen LB, Zhang ZH, Liang YN, Liu S, Cha H, Yang D, Zhai Y, Komatsu T, Tsuruta F, Li H, Cao C, Li Wei, Li GH, Cheng Y, Chiba T, Wang L, Goldberg AL, Shen Y, Qui XB.
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Journal Title
Cell
Volume: 153
Pages: 1012-1024
Peer Reviewed
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