2013 Fiscal Year Final Research Report
Functional analysis of the RNA-binding protein Mei2, which is a key player for meiosis in fission yeast
| Project/Area Number |
23570223
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Kazusa DNA Research Institute (2012-2013)
The University of Tokyo (2011) |
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Principal Investigator |
YAMASHITA Akira 公益財団法人かずさＤＮＡ研究所, ヒトゲノム研究部, 室長 (30312276)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 減数分裂 / RNA結合タンパク質 / 分裂酵母 |
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| Research Abstract |
The goal of this study is to understand the molecular mechanisms underlying meiosis, which is a special type of cell division for gametogenesis. Mei2 is an RNA-binding protein, which is a key player for both the induction and progression of meiosis in fission yeast. It has been shown by this study that activated Mei2 can enhance expression of a transcription factor Ste11 through a positive feedback loop involving the stress-responsive MAP kinase pathway. Furthermore, it has turned out that Mei2 is phosphorylated in mitotically growing cells depending on one of the two TOR kinase complexes in fission yeast, namely TORC1, and is degraded through the ubiquitin-proteasome pathway.
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[Journal Article] Cuf2 boosts the transcription of APC/C activator Fzr1 to terminate the meiotic division cycle2013
Author(s)
Aoi, Y., Arai, K., Miyamoto, M., Katsuta, Y., Yamashita, A., Sato, M., and Yamamoto, M.
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Journal Title
EMBO reports
Volume: 14
Pages: 553-560
Peer Reviewed
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[Journal Article] Psk1, an AGC kinase family member in fission yeast, is directly phosphorylated and controlled by TORC1 as S6 kinase2012
Author(s)
Nakashima, A., Otsubo, Y., Yamashita, A., Sato, T., Yamamoto, M., and Tamanoi, F.
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Journal Title
Journal of Cell Science
Volume: 2
Pages: 5840-5849
Peer Reviewed
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[Journal Article] Mmi1 RNA surveillance machinery directs RNAi complex RITS to specific meiotic genes in fission yeast2012
Author(s)
Hiriart, E., Vavasseur, A., Touat-Todeschini L., Yamashita, A., Gilquin, B., Lambert, E., Perot, J., Shichino, Y., Nazaret, N., Boyault, C., Lachuer, J., Perazza, D., Yamamoto, M., and Verdel, A.
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Journal Title
EMBO J.
Volume: 31
Pages: 2296-2308
Peer Reviewed
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[Journal Article] Hexanucleotide motifs meidate recruitment of the RNA elimination machinery to silent meiotic genes2012
Author(s)
Yamashita, A., Shichino, Y., Tanaka, H., Hiriart, E., Touat-Todeschini, L., Vavasseur, A., Ding, D-Q., Hiraoka, Y., Verdel, A., and Yamamoto, M.
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Journal Title
Open Biology
Volume: 2
Pages: 120014
Peer Reviewed
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[Journal Article] Pob1 ensures cylindrical cell shape by coupling two distinct Rho signaling events during secretory vesicle targeting2011
Author(s)
Nakano, K., Toya, M., Yoneda, A., Asami, Y., Yamashita, A., Kamasawa, N., Osumi, M., and Yamamoto, M.
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Journal Title
Traffic
Volume: 12
Pages: 726-739
Peer Reviewed
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