2014 Fiscal Year Final Research Report
Integration and regulatory mechanism for growth factor and cell adhesion signals
| Project/Area Number |
23570227
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MEKADA Eisuke 大阪大学, 微生物病研究所, 教授 (20135742)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Keywords | 増殖因子 / 細胞接着 |
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| Outline of Final Research Achievements |
To elucidate regulatory mechanism for integration of growth factor signal and cell adhesion signal, role of FAK, which is a common downstream signaling molecule of EGFR and integrin, and its regulatory mechanisms were examined. As a result, FAK was found out to be required for EGFR-dependent cell growth. Furthermore, a FAK mutant carrying phosphorylation-mimic mutation at FERM domain inhibited cell growth by interacting with microtubules through chaperones. Taken together these results, it was suggested that FAK could positively and negatively regulate cell growth depending on phosphorylation states of FERM domain.
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| Free Research Field |
細胞生物学
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