• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2014 Fiscal Year Final Research Report

Analysis of regulatory mechanisms of newly identified ERK substrates

Research Project

  • PDF
Project/Area Number 23570231
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cell biology
Research InstitutionThe University of Tokushima

Principal Investigator

KOSAKO Hidetaka  徳島大学, 藤井節郎記念医科学センター, 教授 (10291171)

Co-Investigator(Renkei-kenkyūsha) SAITOH Hisato  熊本大学, 大学院自然科学研究科, 教授 (50211925)
TSUMOTO Kouhei  東京大学, 大学院工学系研究科, 教授 (90271866)
Project Period (FY) 2011-04-28 – 2015-03-31
KeywordsERK / MAPキナーゼ / リン酸化 / 細胞内情報伝達 / 細胞運動 / 抗リン酸化抗体 / プロテオーム
Outline of Final Research Achievements

ERK/MAP kinase is evolutionally conserved in eukaryotes and plays multiple and important roles in cells by phosphorylating various substrates. We have recently identified new ERK substrates by developing a phosphoproteomic approach. In this study, we identified phosphorylation sites of several of these ERK substrates and biochemically analyzed phosphorylation-dependent regulation of their functions. Furthermore, each ERK substrate was shown to be involved in ERK-mediated regulation of cellular functions.

Free Research Field

生物学

URL: 

Published: 2016-06-03  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi