2013 Fiscal Year Final Research Report
Role of VCIP135 in Golgi reorganization
| Project/Area Number |
23570234
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Kyushu University |
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Principal Investigator |
TOTSUKAWA Go 九州大学, 医学(系)研究科(研究院), 助教 (90399684)
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| Project Period (FY) |
2011 – 2013
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| Keywords | ゴルジ体 / VCIP135 / ユビキチン化 |
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| Research Abstract |
A novel VCIP135 binding protein is identified as WAC. WAC directly binds to VCIP135, and activates deubiquitinase activity of VCIP135 in vitro. WAC localizes to the Golgi, and functions as an essential factor for Golgi biogenesis. Interestingly, in Golgi reassembly, WAC functions only in p97/p47 membrane fusion pathway, but not in p97/p37 membrane fusion pathway. On the other hand, WAC has no function in ER biogenesis at all. It is suggested that ubiquitin signaling mediated by VCIP135/WAC plays a specific role in Golgi biogenesis, especially in mitosis.
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[Journal Article] VCIP135 deubiquitinase and its binding protein, WAC, in p97ATPase-mediated membrane fusion2011
Author(s)
Totsukawa, G., Kaneko, Y., Uchiyama, K., Toh, H., Tamura, K., and Kondo, H.
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Journal Title
EMBO Journal.
Volume: 30(17)
Pages: 3581-3593
DOI
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