2014 Fiscal Year Final Research Report
Roles of cholesterol synthetic pathway during embryonic development
| Project/Area Number |
23570246
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Tohoku University |
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Principal Investigator |
SHOJI Wataru 東北大学, 学際科学フロンティア研究所, 准教授 (40250831)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Keywords | zebrafish / blood vessel / cholosterol |
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| Outline of Final Research Achievements |
Our previous study indicated Zebrafish mutant that has defect in cholesterol synthesis pathway exhibits blood vessel development. In this study, we report geranyl-geranyl products that derive from intermediate metabolite of this pathway, is essential for blood vessel development. Prenyl modification activates numbers of small G proteins, and we found rab family members are involved in the blood vessel formation. We are further investigating if same mechanism is conserved in mammalian blood vessels.
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| Free Research Field |
Developmental biology
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