2013 Fiscal Year Final Research Report
Regulation of neocortical neuronal migration by the PDK1-Akt pathway
| Project/Area Number |
23570249
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ITOH Yasuhiro 東京大学, 分子細胞生物学研究所, 助教 (50508108)
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| Co-Investigator(Kenkyū-buntansha) |
GOTOH Yukiko 東京大学, 薬学系研究科, 教授 (70252525)
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| Project Period (FY) |
2011 – 2013
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| Keywords | ニューロン移動 / Akt |
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| Research Abstract |
In the developing mammalian neocortex, neurons born within the inner pseudostratified layer ventricular zone migrate long distance radially toward outer region to form orderly aligned six layers within the cortical plate. Given that proper lamination of neocortex depends on timely and sequential arrival of functionally distinct neurons at the brain surface, regulation of the speed of migrating neurons is important, although the underlying mechanism remains unclear. Our results indicate that the PDK1-Akt pathway plays a crucial role in regulation of neuronal motility possibly through regulation of microtubule stability/dynamics and nucleus-centrosome coupling.
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